Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased expression of the blood group-related Lewis Y antigen on synovial fluid granulocytes of patients with arthritic joint diseases
Autore:
Dettke, M; Palfi, G; Pursch, E; Fischer, MB; Loibner, H;
Indirizzi:
Univ Hosp Vienna, AKH Vienna, Dept Blood Grp Serol & Transfus Med, Vienna,Austria Univ Hosp Vienna Vienna Austria rp Serol & Transfus Med, Vienna,Austria NOVARTIS Forschungsinst, Vienna, Austria NOVARTIS Forschungsinst Vienna Austria Forschungsinst, Vienna, Austria
Titolo Testata:
RHEUMATOLOGY
fascicolo: 9, volume: 40, anno: 2001,
pagine: 1033 - 1037
SICI:
1462-0324(200109)40:9<1033:IEOTBG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS; ADHESION MOLECULES; PERIPHERAL-BLOOD; MONOCLONAL-ANTIBODY; LE(Y) OLIGOSACCHARIDE; RECEPTOR EXPRESSION; SELECTIN; NEUTROPHILS; OSTEOARTHRITIS; GLYCOPROTEIN;
Keywords:
Lewis antigens; granulocytes; joint disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Dettke, M Univ Vienna, AKH Vienna, Dept Blood Grp Serol & Transfus Med, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
M. Dettke et al., "Increased expression of the blood group-related Lewis Y antigen on synovial fluid granulocytes of patients with arthritic joint diseases", RHEUMATOLOG, 40(9), 2001, pp. 1033-1037

Abstract

Objective. To evaluate the expression of the carbohydrate structures LewisY (LeY), sialyl-LeX (sLeX) and Lewis X (LeX) on paired peripheral blood (PB) and synovial fluid (SF) granulocytes in patients with arthritic diseases. Methods. Ten patients with rheumatoid arthritis (RA), seven patients with spondyloarthritis (SA) and eight patients with osteoarthritis (OA) were studied. Granulocyte expression of the Le oligosaccharides was analysed by fluorescence-activated cell sorting. Results. SF granulocytes of patients with RA, SA and OA expressed higher levels of the LeY oligosaccharide than PB granulocytes. Increases in LeY on SF granulocytes were similar in all three underlying diseases. No differences in the expression of the Le antigens were detected between PB granulocytes of patients and healthy individuals. Expression of sLeX and LeX showed no variation between SF and PB neutrophils. Conclusion. The selective increase in LeY antigen on SF granulocytes in RA, SA and OA suggests a role of the LeY oligosaccharide in granulocyte traffic and inflammatory responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:23:40