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Titolo:
IgG subclass distribution of antibodies against beta(2)-GP1 and cardiolipin in patients with systemic lupus erythematosus and primary antiphospholipid syndrome, and their clinical associations
Autore:
Samarkos, M; Davies, KA; Gordon, C; Walport, MJ; Loizou, S;
Indirizzi:
Evangelismos Med Ctr, Dept Internal Med 5, Athens 10676, Greece Evangelismos Med Ctr Athens Greece 10676 nal Med 5, Athens 10676, Greece Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Div Med,Rheumatol Sect, London, England Univ London Imperial Coll Sci Technol& Med London England don, England Univ Birmingham, Dept Rheumatol, Div Immun & Infect, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 9, volume: 40, anno: 2001,
pagine: 1026 - 1032
SICI:
1462-0324(200109)40:9<1026:ISDOAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PLASMA-PROTEINS; PHOSPHOLIPID-BINDING; ANTICARDIOLIPIN ANTIBODIES; RHEUMATOID-FACTOR; BETA(2)-GLYCOPROTEIN-I; BETA-2-GLYCOPROTEIN-I; AUTOANTIBODIES; IMMUNOLOGY; ANTI-BETA(2)-GLYCOPROTEIN-I; MANIFESTATIONS;
Keywords:
systemic lupus erythematosus; anticardiolipin; antiphospholipid antibodies; IgG subclasses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Samarkos, M Evangelismos Med Ctr, Dept Internal Med 5, 45-47 Ipsilantou St, Athens 10676, Greece Evangelismos Med Ctr 45-47 Ipsilantou St Athens Greece 10676
Citazione:
M. Samarkos et al., "IgG subclass distribution of antibodies against beta(2)-GP1 and cardiolipin in patients with systemic lupus erythematosus and primary antiphospholipid syndrome, and their clinical associations", RHEUMATOLOG, 40(9), 2001, pp. 1026-1032

Abstract

Objectives. To determine the immunoglobulin G (IgG) subclass distribution of anticardiolipin (aCL) and anti-beta (2)-glycoprotein 1 (beta (2)-GP1) antibodies (a beta (2)-GP1), and to examine possible associations between thedifferent a beta (2)-GP1 and aCL subclasses and the main clinical manifestations of the antiphospholipid syndrome (APS). Methods. We studied 130 patients with systemic lupus erythematosus and 35 patients with primary APS. We used enzyme-linked immunosorbent assays to measure IgG aCL and a beta (2)-GP1 and to determine the IgG subclass distribution of these two autoantibodies. Results. When the number of patients positive for each subclass was examined, IgG(3) and IgG(2) aCL were more frequent (63.5 and 54.1% of patients were positive for the two subclasses, respectively), while for a beta (2)-GP1IgG(2) was the most prevalent subclass (81.8% of patients were positive). IgG(2) aCL was significantly associated with arterial thrombosis (P=0.023) and fetal loss (P=0.013), and IgG(3) aCL was significantly associated with arterial thrombosis (P=0.0003) and fetal loss (P=0.045). IgG(2) a beta (2)-GP1 was associated with venous thrombosis (P=0.012) and IgG(3) a beta (2)-GP1 was associated with venous thrombosis (P=0.036) and fetal loss (P=0.024). Conclusions. The IgG(2) predominance of a beta (2)-GP1 suggests that the antibody response against beta (2)-GP1 may be T-cell-independent. As IgG(2) and IgG(3) differ in their effector functions, their association with the same clinical manifestations (i.e. thrombosis and fetal loss) suggests that more than one mechanism may be involved in the pathogenesis of thrombosis and fetal loss in APS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:35:24