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Titolo:
Interleukin-1-induced subacromial synovitis and shoulder pain in rotator cuff diseases
Autore:
Gotoh, M; Hamada, K; Yamakawa, H; Yanagisawa, K; Nakamura, M; Yamazaki, H; Ueyama, Y; Tamaoki, N; Inoue, A; Fukuda, H;
Indirizzi:
Kurume Univ, Sch Med, Dept Orthopaed Surg, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 Orthopaed Surg, Fukuoka 8300011, Japan Tokai Univ, Sch Med, Dept Orthopaed Surg, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 rthopaed Surg, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 , Dept Pathol, Kanagawa 2591193, Japan
Titolo Testata:
RHEUMATOLOGY
fascicolo: 9, volume: 40, anno: 2001,
pagine: 995 - 1001
SICI:
1462-0324(200109)40:9<995:ISSASP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IL-1 RECEPTOR ANTAGONIST; RHEUMATOID-ARTHRITIS; BURSA; HYPERALGESIA; INFLAMMATION; EXPRESSION; IL-1-BETA; PROTEIN;
Keywords:
interleukin-1 beta; interleukin-1 receptor antagonist; shoulder pain; subacromial bursa; rotator cuff diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gotoh, M Kurume Univ, Sch Med, Dept Orthopaed Surg, Asahi Machi 67, Fukuoka 8300011, Japan Kurume Univ Asahi Machi 67 Fukuoka Japan 8300011 8300011, Japan
Citazione:
M. Gotoh et al., "Interleukin-1-induced subacromial synovitis and shoulder pain in rotator cuff diseases", RHEUMATOLOG, 40(9), 2001, pp. 995-1001

Abstract

Objective. To determine the relationship between the expression of interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonists (IL-1ra) in the subacromial bursa and shoulder pain in rotator cuff diseases. Methods. Synovial specimens were analysed using various methods including reverse transcriptase-polymerase chain reaction (RT-PCR), immunohistochemistry and in situ RT-PCR. Thirty-nine patients with rotator cuff diseases were candidates. The degree of their shoulder pain was evaluated using a visual analogue scale. Results. The mRNA expression levels of the cytokines were significantly correlated with the degree of pain [IL-1 beta: r=0.782; secreted IL-1ra (sIL-1ra): r=0.756; intracellular IL-1ra (icIL-1ra): r=0.806, P <0.001, respectively]. The combined results of immunohistochemistry and in situ RT-PCR analysis indicated that both synovial lining and sublining cells produce IL-1 beta, while synovial lining cells predominantly produce icIL-1ra and sublining cells secrete sIL-1ra. Conclusions. The differential regulation of the two forms of IL-1ra mRNAs may play an important role in shoulder pain in rotator cuff diseases, regulating IL-1-induced subacromial synovitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:29:22