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Titolo:
Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate
Autore:
Richards, PJ; Williams, BD; Williams, AS;
Indirizzi:
Univ Wales Coll Med, Rheumatol Res Lab, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF14 4XN CF14 4XN, S Glam, Wales
Titolo Testata:
RHEUMATOLOGY
fascicolo: 9, volume: 40, anno: 2001,
pagine: 978 - 987
SICI:
1462-0324(200109)40:9<978:SOCSCW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SYNOVIAL LINING CELLS; COLLAGEN-INDUCED ARTHRITIS; FACTOR-ALPHA CA2; RHEUMATOID-ARTHRITIS; GROUP-A; INFLAMMATORY ARTHRITIS; CARTILAGE DESTRUCTION; INDUCED POLYARTHRITIS; MONOCLONAL-ANTIBODY;
Keywords:
streptococcal cell wall-induced arthritis; macrophages; liposomal clodronate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Richards, PJ Univ Wales Coll Med, Rheumatol Res Lab, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Heath Pk Cardiff S Glam Wales CF144XN es
Citazione:
P.J. Richards et al., "Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate", RHEUMATOLOG, 40(9), 2001, pp. 978-987

Abstract

Objectives. To investigate the role of macrophages in the pathogenesis of chronic streptococcal cell wall (SCW)-induced arthritis using liposomal clodronate. Methods. Female Lewis rats with SCW-induced arthritis received a single intravenous injection of 20 mg of clodronate encapsulated within small unilamellar vesicles (SUVc) 10 days post-arthritis induction. Results. SUVc significantly suppressed the development of chronic SCW-induced arthritis for up to 26 days after treatment. At this time point, ED1(+)macrophages were significantly depleted in the liver and ankle joints, although splenic macrophage numbers were not significantly different from control groups. Macrophage elimination induced a significant reduction in locallevels of interleukin (IL)-1 beta, IL-6, tumour necrosis factor-alpha (TNFalpha) and matrix metalloproteinase-9 (MMP-9) from ankle joints. Conclusions. Macrophage elimination by SUVc inhibits local production of IL-1 beta, IL-6, TNF alpha and MMP-9, and the pathogenesis of inflammatory arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 15:26:02