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Titolo:
THE BETA-CELL GLUCOKINASE PROMOTER VARIANT IS AN UNLIKELY RISK FACTORFOR DIABETES-MELLITUS
Autore:
LOTFI K; SUND G; LOWE R; GRAHAM J; LANDINOLSSON M; KOCKUM I; DEEB S; LERNMARK A;
Indirizzi:
UNIV WASHINGTON,DEPT MED,ROBERT H WILLIAMS LAB,BOX 357710 SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED,ROBERT H WILLIAMS LAB SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT GENET SEATTLE WA 98195 UNIV LUND HOSP,DEPT MED S-22185 LUND SWEDEN KAROLINSKA HOSP,DEPT MOL MED,CLIN GENET UNIT S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Diabetologia
fascicolo: 8, volume: 40, anno: 1997,
pagine: 959 - 962
SICI:
0012-186X(1997)40:8<959:TBGPVI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DECARBOXYLASE-ANTIBODIES; SWEDISH CHILDREN; GENETIC-MARKER; ISLET-CELL; NIDDM; IDDM; LINKAGE; LOCUS; ONSET; ASSOCIATION;
Keywords:
IDDM; NIDDM; GLUCOKINASE GENE; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATIONAL POLYMORPHISM; ISLET CELL ANTIBODIES; GAD65 ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Lotfi et al., "THE BETA-CELL GLUCOKINASE PROMOTER VARIANT IS AN UNLIKELY RISK FACTORFOR DIABETES-MELLITUS", Diabetologia, 40(8), 1997, pp. 959-962

Abstract

Glucokinase plays an important role in the regulation of insulin secretion and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Asingle G-A nucleotide polymorphism at the -30 position of the beta-cell specific promoter region of the glucokinase gene was previously associated with reduced beta-cell function. In the present study we analysed 268 consecutive newly diagnosed Swedish patients classified with either IDDM (n = 205), NIDDM (n = 31) or unclassifiable (n = 32) diabetes between the ages of 15 and 35 years along with a group of 158 age- and sex-matched control subjects. The beta-cell promoter region was amplified by the polymerase chain reaction and the G-A variant identified by single strand conformational polymorphism. There was no significant difference in allele frequencies of G and A between any of the subject groups and likewise, no significant difference in the frequencies of the G/G, G/A, or A/A genotypes. Eight subjects were homozygous for the less common A allele, five had IDDM and three were control subjects. Our results suggest that the -30 beta-cell glucokinase promoter variant is not associated with IDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:58:18