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Titolo:
Cannabis induced dopamine release: an in-vivo SPECT study
Autore:
Voruganti, LNP; Slomka, P; Zabel, P; Mattar, A; Awad, AG;
Indirizzi:
Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 d Sci, Toronto, ON M5S 1A1, Canada Univ Western Ontario, Dept Psychiat, London, ON, Canada Univ Western Ontario London ON Canada Dept Psychiat, London, ON, Canada Univ Western Ontario, Dept Nucl Med, London, ON, Canada Univ Western Ontario London ON Canada Dept Nucl Med, London, ON, Canada
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 107, anno: 2001,
pagine: 173 - 177
SICI:
0925-4927(20011001)107:3<173:CIDRAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA; TRANSMISSION; ABUSE;
Keywords:
psychosis; cannabinoids; schizophrenia; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Voruganti, LNP Schizophrenia Treatment & Res Program, 850 Highbury Ave, London, ON N6A 4H1, Canada Schizophrenia Treatment & Res Program 850 HighburyAve London ON Canada N6A 4H1
Citazione:
L.N.P. Voruganti et al., "Cannabis induced dopamine release: an in-vivo SPECT study", PSYCH RES-N, 107(3), 2001, pp. 173-177

Abstract

In a research study aimed at examining the alterations in dopaminergic function in schizophrenia, the authors identified a surreptitious case scenario which provided new insights into the subjective and neurochemical effectsof cannabis. A 38-year-old drug-free schizophrenic patient took part in a single photon emission computerized tomographic (SPECT) study of the brain,and smoked cannabis secretively during a pause in the course of an imagingsession. Cannabis had an immediate calming effect, followed by a worseningof psychotic symptoms a few hours later. A comparison of the two sets of images, obtained before and immediately after smoking cannabis, indicated a 20% decrease in the striatal dopamine D-2 receptor binding ratio, suggestive of increased synaptic dopaminergic activity. This observation offers a plausible biological explanation for the psychotogenic effects of cannabis invulnerable individuals, and also raises speculations about an interaction between cannabinoid and dopaminergic systems in the brain reward pathways. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:13:40