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Titolo:
EEG coherence in post-LSD visual hallucinations
Autore:
Abraham, HD; Duffy, FH;
Indirizzi:
Mt Auburn Hosp, Dept Psychiat, Cambridge, MA 02138 USA Mt Auburn Hosp Cambridge MA USA 02138 t Psychiat, Cambridge, MA 02138 USA Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Neurol, Boston, MA 02115 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 107, anno: 2001,
pagine: 151 - 163
SICI:
0925-4927(20011001)107:3<151:ECIPVH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR-BINDING; CORTEX; SYNCHRONIZATION; OSCILLATIONS; DEPENDENCE; REDUCTION; SPECT; ZONE; CAT;
Keywords:
LSD; hallucinogen persisting perception disorder (HPPD); drug abuse; qEEG; spectral coherence; cortical connectivity; visual hallucinations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Abraham, HD 175 Bedford St, Lexington, MA 02420 USA 175 Bedford St Lexington MA USA 02420 Lexington, MA 02420 USA
Citazione:
H.D. Abraham e F.H. Duffy, "EEG coherence in post-LSD visual hallucinations", PSYCH RES-N, 107(3), 2001, pp. 151-163

Abstract

LSD use in certain individuals may result in chronic visual hallucinations, a DSM-IV syndrome known as hallucinogen persisting perception disorder (HPPD). We studied 38 HPPD subjects with a mean of 9.7 years of persistent visual hallucinations and 33 control subjects. Measures of local and medium distance EEG spectral coherence were calculated from all subjects. Coherence, a measure of spectral similarity over time, may estimate cortical coupling. In the eyes-open state in HPPD subjects, widespread reduction of coherence was noted. However, upon eye closure, the occipital region demonstrated augmented regional coherence over many frequencies but with reduced coherence of the occipital region to more distant regions. This occipital coherence increase correlated with previously reported shortened occipital visual evoked potential latency for HPPD subjects. We speculate from coherence and known clinical and psychophysical data that, in HPPD, there is widespread cortical inhibition in the eyes-opened state, but localized and isolated occipital disinhibition upon eye closure, a state known to facilitate hallucinatory experiences. An analogy is drawn to findings in the interictal and ictal epileptic focus. In HPPD, we speculate that occipital EEG hypersynchrony resulting from increased regional coherence, when coupled with relative isolation of visual cortex, especially upon eye closure, facilitates hallucinations and illusions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:43:41