Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The hypothalamus and hypertension
Autore:
De Wardener, HE;
Indirizzi:
Imperial Coll Sch Med, Dept Clin Chem, London W6 8RP, England Imperial Coll Sch Med London England W6 8RP Chem, London W6 8RP, England
Titolo Testata:
PHYSIOLOGICAL REVIEWS
fascicolo: 4, volume: 81, anno: 2001,
pagine: 1599 - 1658
SICI:
0031-9333(200110)81:4<1599:THAH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ATRIAL-NATRIURETIC-PEPTIDE; CENTRAL-NERVOUS-SYSTEM; CORTICOTROPIN-RELEASING-FACTOR; CHRONIC-RENAL-FAILURE; ROSTRAL VENTROLATERAL MEDULLA; SALT-INDUCED HYPERTENSION; WISTAR-KYOTO RATS; RENIN-ANGIOTENSIN SYSTEM; KALLIKREIN-KININ SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
709
Recensione:
Indirizzi per estratti:
Indirizzo: De Wardener, HE Imperial Coll Sch Med, Dept Clin Chem, Charing Cross Campus,St Dunstans Rd, London W6 8RP, England Imperial Coll Sch Med Charing Cross Campus,St Dunstans Rd London England W6 8RP
Citazione:
H.E. De Wardener, "The hypothalamus and hypertension", PHYSIOL REV, 81(4), 2001, pp. 1599-1658

Abstract

Most forms of hypertension are associated with a wide variety of functional changes in the hypothalamus. Alterations in the following substances are discussed: catecholamines, acetylcholine, angiotensin II, natriuretic peptides, vasopressin, nitric oxide, serotonin, GABA, ouabain, neuropeptide Y, opioids, bradykinin, thyrotropin-releasing factor, vasoactive intestinal polypeptide, tachykinins, histamine, and corticotropin-releasing factor. Functional changes in these substances occur throughout the hypothalamus but areparticularly prominent rostrally; most lead to an increase in sympathetic nervous activity which is responsible for the rise in arterial pressure. A few appear to be depressor compensatory changes. The majority of the hypothalamic changes begin as the pressure rises and are particularly prominent in the young rat; subsequently they tend to fluctuate and overall to diminish with age. It is proposed that, with the possible exception of the Dahl salt-sensitive rat, the hypothalamic changes associated with hypertension arecaused by renal and intrathoracic cardiopulmonary afferent stimulation. Renal afferent stimulation occurs as a result of renal ischemia and trauma asin the reduced renal mass rat. It is suggested that afferents from the chest arise, at least in part, from the observed increase in left auricular pressure which, it is submitted, is due to the associated documented impairedability to excrete sodium. It is proposed, therefore, that the hypothalamic changes in hypertension are a link in an integrated compensatory natriuretic response to the kidney's impaired ability to excrete sodium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:53:03