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Titolo:
BEHAVIORAL REACTIVITY TO AVERSIVE STIMULI IN A TRANSGENIC MOUSE MODELOF IMPAIRED GLUCOCORTICOID (TYPE-II) RECEPTOR FUNCTION - EFFECTS OF DIAZEPAM AND FG-7142
Autore:
ROCHFORD J; BEAULIEU S; ROUSSE I; GLOWA JR; BARDEN N;
Indirizzi:
DOUGLAS HOSP,RES CTR,6875 LASALLE BLVD VERDUN PQ H4H 1R3 CANADA NIMH,BIOL PSYCHIAT BRANCH BETHESDA MD 20014 NIDDK BETHESDA MD 20014 UNIV LAVAL,CHU LAVAL,RES CTR,DEPT PHYSIOL,MOL PSYCHOGENET LAB ST FOY PQ G1K 7P4 CANADA
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 132, anno: 1997,
pagine: 145 - 152
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; ANTISENSE RNA; ANXIETY; MICE; VALIDATION; AXIS; FEAR;
Keywords:
TRANSGENIC MOUSE; DIAZEPAM; FG-7142; GLUCOCORTICOID RECEPTOR; AVERSIVE STIMULI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J. Rochford et al., "BEHAVIORAL REACTIVITY TO AVERSIVE STIMULI IN A TRANSGENIC MOUSE MODELOF IMPAIRED GLUCOCORTICOID (TYPE-II) RECEPTOR FUNCTION - EFFECTS OF DIAZEPAM AND FG-7142", Psychopharmacology, 132(2), 1997, pp. 145-152

Abstract

Transgenic mice with impaired type II-glucocorticoid receptor mediated feedback inhibition of hypthalamic-pituitary-adrenal activity were assessed in three different tests assessing behavioral reactivity to aversive stimuli, the elevated plus maze, the Thatcher-Britton novelty-conflict paradigm, and the startle paradigm. Transgenic mice more frequently entered and spent more time in the open arms of the elevated plus in comparison to B6C/3F1 mice. Transgenic mice took significantly longer to begin eating in the Thatcher-Britton novelty conflict paradigm, and displayed increased reactivity in the startle paradigm. Administration of 1 or 2 mg/kg diazepam reversed the behavioral effects observed in all three tests. Administration of the benzodiazepine receptor inverse agonist N-methyl-beta-carboline-3 carboxamide (FG-7142, 10 mg/kg) reduced the ratio of open to total arm entries and the time spent in the open arms of the plus maze in transgenic, but not B6C/3F1, mice. This dose of FG-7142 did not influence performance of either strain in the Thatcher-Britton or startle paradigms. These results are discussed in terms of the hypothesis that the transgenic mice are more sensitive to the aversive properties of novel stimuli, and that they may have difficulty discriminating between signals of relative safety and danger.

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Documento generato il 07/07/20 alle ore 12:27:17