Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hematologic and chemical changes observed during and after cardiac arrest in a canine model - A pilot study
Autore:
Bleske, BE; Song, J; Chow, MSS; Kluger, J; White, CM;
Indirizzi:
Hartford Hosp, Drug Informat Ctr, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 Informat Ctr, Hartford, CT 06102 USA Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Coll Pharm, Ann Arbor, MI 48109 USA Hartford Hosp, Dept Pharm, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 p, Dept Pharm, Hartford, CT 06102 USA Hartford Hosp, Dept Cardiol, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 Dept Cardiol, Hartford, CT 06102 USA Univ Connecticut, Sch Pharm, Storrs, CT USA Univ Connecticut Storrs CT USA iv Connecticut, Sch Pharm, Storrs, CT USA Univ Connecticut, Sch Med, Storrs, CT 06268 USA Univ Connecticut Storrs CT USA 06268 ticut, Sch Med, Storrs, CT 06268 USA Univ Connecticut, Sch Pharm, Farmington, CT USA Univ Connecticut Farmington CT USA cticut, Sch Pharm, Farmington, CT USA Univ Connecticut, Sch Med, Farmington, CT USA Univ Connecticut FarmingtonCT USA necticut, Sch Med, Farmington, CT USA Chinese Univ Hong Kong, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 10, volume: 21, anno: 2001,
pagine: 1187 - 1191
SICI:
0277-0008(200110)21:10<1187:HACCOD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR-FIBRILLATION; RESUSCITATION; DOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: White, CM Hartford Hosp, Drug Informat Ctr, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 Ctr, Hartford, CT 06102 USA
Citazione:
B.E. Bleske et al., "Hematologic and chemical changes observed during and after cardiac arrest in a canine model - A pilot study", PHARMACOTHE, 21(10), 2001, pp. 1187-1191

Abstract

Study Objective. To evaluate the effect of cardiac arrest and cardiopulmonary resuscitation (CPR) on blood chemistry in a canine model. Design. Evaluative canine animal study. Setting. Animal laboratory accredited by the Association for Assessment and Accreditation of Laboratory Animals. Subjects. Twenty-six adult mongrel dogs. Intervention. The dogs underwent an episode of induced fibrillatory cardiac arrest for 3 minutes followed by 10 minutes of standard CPR. Blood samples were taken at baseline (before cardiac arrest), after 10 minutes of ventricular fibrillation, and 10 minutes after successful resuscitation for determination of blood chemistries and hematologic parameters. Measurements and Main Results. Glucose, blood urea nitrogen, serum creatinine, sodium, potassium, chloride, calcium, phosphorus, uric acid, alkaline phosphatase, lactate dehydrogenase, aspartate amino transferase, alanine amino transferase, protein, albumin, cholesterol, triglycerides, iron, white blood cell count, red blood cell count, and hematocrit were measured. Significant changes (p<0.05) in values obtained during CPR versus baseline values were noted for all laboratory parameters except blood urea nitrogen, chloride, and alkaline phosphatase. Eighteen dogs achieved return of spontaneous circulation (ROSC); their laboratory values were obtained after CPR. Significant changes (p<0.05) after ROSC compared with baseline were noted for all laboratory values except chloride, blood urea nitrogen, uric acid, alkaline phosphatase, glucose, potassium, calcium, triglycerides, iron, red blood cell count, and hematocrit. Conclusion. Results indicate that significant changes in blood chemistriesand hematologic parameters occur during and after CPR. Clinicians should note these normal laboratory parameter changes when interpreting laboratory data in patients who experience cardiac arrest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:51:42