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Titolo:
Dopamine D2 receptor mRNA measured in serial sections of the rat anterior pituitary
Autore:
Piano, JZ; Pogacnik, A;
Indirizzi:
Univ Ljubljana, Fac Vet, Inst Anat Histol & Embryol, Ljubljana 1000, Slovenia Univ Ljubljana Ljubljana Slovenia 1000 Embryol, Ljubljana 1000, Slovenia
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 6, volume: 442, anno: 2001, supplemento:, 1
pagine: R209 - R210
SICI:
0031-6768(2001)442:6<R209:DDRMMI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; INSITU HYBRIDIZATION;
Keywords:
dopamine D2 receptor; in situ hybridization; pituitary; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Piano, JZ Univ Ljubljana, Fac Vet, Inst Anat Histol & Embryol, Gerbiceva 60, Ljubljana 1000, Slovenia Univ Ljubljana Gerbiceva 60 Ljubljana Slovenia1000 0, Slovenia
Citazione:
J.Z. Piano e A. Pogacnik, "Dopamine D2 receptor mRNA measured in serial sections of the rat anterior pituitary", PFLUG ARCH, 442(6), 2001, pp. R209-R210

Abstract

Dopamine D2 receptors (D2-Rs) on lactotrophs in the pituitary gland are targets for dopamine to inhibit prolactin synthesis and release. The aim of our study was to examine if subpopulations of cells in the anterior pituitary that respond differently to dopamine show different pattern of D2-R mRNA expression. Therefore, we have used quantitative in situ hybridization technique to study the localisation of D2-R mRNA in the rat adenohypophysis. Pituitary tissue was obtained from mature and 18 days old rats. Riboprobe wastranscribed from rat pituitary cDNA clone encoding D2-R and hybridized in situ with the serial sections of the pituitaries. Our results show that, although the anterior lobe of the pituitary gland contains a variety of cell types distributed in clusters, D2-R mRNA is relatively evenly distributed through the adenohypophysis. Level of expression of D2-R mRNA in the pituitary is slightly higher in mature than in young rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:47:08