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Titolo:
Circadian and concentration profile of cathepsin S in sera from healthy subjects and asthmatic patients
Autore:
Cimerman, N; Brguljan, PM; Krasovec, M; Suskovic, S; Kos, J;
Indirizzi:
KRKA DD, Div Res & Dev, Dept Biochem Res & Drug Design, Ljubljana 1000, Slovenia KRKA DD Ljubljana Slovenia 1000 & Drug Design, Ljubljana 1000, Slovenia Univ Clin Resp & Allerg Dis, Golnik, Slovenia Univ Clin Resp & Allerg DisGolnik Slovenia llerg Dis, Golnik, Slovenia Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana, Slovenia Jozef Stefan Inst Ljubljana Slovenia em & Mol Biol, Ljubljana, Slovenia
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 6, volume: 442, anno: 2001, supplemento:, 1
pagine: R204 - R206
SICI:
0031-6768(2001)442:6<R204:CACPOC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE PROTEINASES; CYSTATIN-C; CELLS;
Keywords:
asthma; cathepsin S; cyclosporin A; methylprednisolone; serum; 24-h variations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Cimerman, N KRKA DD, Div Res & Dev, Dept Biochem Res & Drug Design, Cesta Brdo 49, Ljubljana 1000, Slovenia KRKA DD Cesta Brdo 49 Ljubljana Slovenia1000 1000, Slovenia
Citazione:
N. Cimerman et al., "Circadian and concentration profile of cathepsin S in sera from healthy subjects and asthmatic patients", PFLUG ARCH, 442(6), 2001, pp. R204-R206

Abstract

Cathepsin S (CS) has been proposed to be associated with asthma pathogenesis but its exact role is not established. In order to understand this proposed association our objective was to follow the 24-h concentration pattern of CS in sera from apparently healthy subjects and from steroid-independentand steroid-dependent asthmatics before and after one weeks' treatment with methylprednisolone (MP) and cyclosporin A (CsA), respectively. Blood samples were collected every 4 h over a 24-h period. Statistical evaluation of data for time effect was performed by one way ANOVA and least-squares fit of 24-h cosine. Little or no significant change of CS concentrations with time over a 24-h period was observed in healthy and asthmatic sera. CS concentrations were significantly lower in steroid-independent asthmatics compared to controls while there was no difference between healthy subjects and steroid-dependent asthmatics. After one week of therapy MP decreased CS concentrations while CsA had no effect. Our data suggest the involvement of CS in asthma pathogenesis and the potential use of CS levels as an additional biological parameter for monitoring the extent of disease and response to therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 06:38:12