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Titolo:
OCULAR ABNORMALITIES IN CHRONIC-SCHIZOPHRENIA - CLINICAL IMPLICATIONS
Autore:
SMITH D; PANTELIS C; MCGRATH J; TANGAS C; COPOLOV D;
Indirizzi:
MENTAL HLTH RES INST,LOCKED BAG 11 PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT PSYCHIAT MELBOURNE VIC AUSTRALIA ROYAL MELBOURNE HOSP MELBOURNE VIC AUSTRALIA WOLSTON PK HOSP,QUEENSLAND CTR SCHIZOPHRENIA RES BRISBANE QLD AUSTRALIA ROYAL VICTORIAN EYE & EAR HOSP,E MELBOURNE EYE GRP MELBOURNE VIC 3002AUSTRALIA
Titolo Testata:
Australian and New Zealand Journal of Psychiatry
fascicolo: 2, volume: 31, anno: 1997,
pagine: 252 - 256
SICI:
0004-8674(1997)31:2<252:OAIC-C>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ENUCLEATION; PSYCHOSIS; DISEASE; EYE;
Keywords:
CHRONIC SCHIZOPHRENIA; EYE TOXICITY; NEUROLEPTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
D. Smith et al., "OCULAR ABNORMALITIES IN CHRONIC-SCHIZOPHRENIA - CLINICAL IMPLICATIONS", Australian and New Zealand Journal of Psychiatry, 31(2), 1997, pp. 252-256

Abstract

Objective: As part of a randomised double-blind study of a new atypical antipsychotic we sought to determine both the levels of visual acuity and the occurrence of toxic side-effects in a group of patients treated for many years on a variety of antipsychotics. Method: Twenty-three inpatients with a DSM-III-R diagnosis of chronic schizophrenia fromtwo separate hospital locations who met the criteria for the double-blind trial were examined for ocular abnormalities at both baseline andat trial completion. Results: At baseline a high prevalence of abnormalities was identified: 19 patients (82.6%) were found to have one or more ocular abnormalities, including lens opacities/cataracts and corneal pigmentation; three patients, with delusions related to the sun, were noted to have solar burns; a high proportion (almost 70%) of patients had untreated visual acuity problems. No further changes were observed at the follow-up examinations. Conclusions: The possible causes of ocular disturbance in schizophrenia and the reasons for the relatively high ocular morbidity in this group are thought to result from bothillness-related factors and the effects of antipsychotic medication. Causality is confounded by a number of issues such as the high prevalence of smoking, poor general health and the variety of antipsychotic medications used in the treatment of psychosis as well as substance abuse. The clinical implications are considered in this paper in relationto the move towards community-based psychiatric services.

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Documento generato il 28/11/20 alle ore 04:43:59