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Titolo:
Monitoring of the Pseudomonas aeruginosa sensitivity to antibiotics in France and spreading of betalactamine resistance mechanisms: GERPB 1999 study
Autore:
Cavallo, JD; Leblanc, F; Fabre, R; Fourticq-Esqueoute, A;
Indirizzi:
Hop Instruct Armees Begin, Serv Biol Med, F-94163 St Mande, France Hop Instruct Armees Begin St Mande France F-94163 94163 St Mande, France Lab Glaxo Smithkline, Marly Le Roi, France Lab Glaxo Smithkline Marly Le Roi France ithkline, Marly Le Roi, France
Titolo Testata:
PATHOLOGIE BIOLOGIE
fascicolo: 7, volume: 49, anno: 2001,
pagine: 534 - 539
SICI:
0369-8114(200109)49:7<534:MOTPAS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
FRE
Soggetto:
METALLO-BETA-LACTAMASE; SUSCEPTIBILITY; SEROTYPES; PATTERNS; GENE;
Keywords:
France; Pseudomonas aeruginosa; resistance mechanisms; susceptibility to antibiotics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Cavallo, JD Hop Instruct Armees Begin, Serv Biol Med, 69 Ave Paris, F-94163 St Mande, France Hop Instruct Armees Begin 69 Ave Paris St Mande France F-94163
Citazione:
J.D. Cavallo et al., "Monitoring of the Pseudomonas aeruginosa sensitivity to antibiotics in France and spreading of betalactamine resistance mechanisms: GERPB 1999 study", PATH BIOL, 49(7), 2001, pp. 534-539

Abstract

A prospective survey was carried out in october 1999 in 15 french teachinghospitals. Average susceptibility rates, determined by minimal inhibitory concentrations, for the 738 non-repetitive strains of R aeruginosa isolatedwere: ticarcillin, 58%, ticarcillin + clavulanic acid, 56%, piperacillin, 73%, piperacillin + tazobactam, 82%, ceftazidime, 76%, cefepime, 53%, cetpirome, 36%, aztreonam, 58%, imipenem, 81%, amikacin, 62%, tobramycine, 71% and, ciprofloxacin, 60%. Among the 75% serotypable strains, the most frequent serotypes were, O : 6 (15.3%), O : 11 (14.5%), O : 1 (10.4%), O : 3 (7.9%), O : 4 (6.1%) and O : 12 (6.1%). The serotype O : 12 was the most resistant to antibiotics. Forty-two percent of the strains were resistant or presented an intermediate susceptibility to ticarcillin. Mechanisms were as follow: 14.5% non enzymatic mechanism, 12.5% overproduction of the constitutivecephalosporinase, 7.1% transferable betalactamase and, 6.9% combination ofthese mechanisms. Among the 67 transferable betalactamases: 48 (71.6%) were PSE-1, 12 (19.4%) TEM-2 and 6 (7.5%) oxacillinases. One extended spectrumbetalactamase was characterized, Among the cephalosporines tested, cefepime was less affected by the overproduction of constitutive cephalosporinase. Ceftazidime, remained the best cephalosporin except against the strains overexpressing the chromosomal type 1 beta-lactamase. Resistance to tobramycin was mainly due to enzymatic mechanisms with a high level of resistance. Decreased susceptibility was more frequent for amikacin than for tobramycin. This was probably related with non enzymatic mechanisms. (C) 2001 Editionsscientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:28:11