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Titolo:
Complex pulmonary vessel alterations due to an aorto-pulmonary window in adulthood
Autore:
Muller, AM; Schulz, F; Muller, KM;
Indirizzi:
Bergmannshell Univ Klin, Berufsgenossenschaftkiche Kliniken, Inst Pathol, D-44789 Bochum, Germany Bergmannshell Univ Klin Bochum Germany D-44789 , D-44789 Bochum, Germany Univ Hamburg, Inst Rechts Med, Hamburg, Germany Univ Hamburg Hamburg Germany Hamburg, Inst Rechts Med, Hamburg, Germany
Titolo Testata:
PATHOLOGE
fascicolo: 5, volume: 22, anno: 2001,
pagine: 349 - 353
SICI:
0172-8113(200109)22:5<349:CPVADT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Soggetto:
AORTOPULMONARY WINDOW; SEPTAL-DEFECT; MANAGEMENT;
Keywords:
aorto-pulmonary window; adult; aneurysm; pulmonary artery; pulmonary hypertension; plexiform lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, AM Bergmannshell Univ Klin, Berufsgenossenschaftkiche Kliniken, Inst Pathol, Burkle Camp Pl 1, D-44789 Bochum, Germany Bergmannshell Univ Klin Burkle Camp Pl 1 Bochum Germany D-44789
Citazione:
A.M. Muller et al., "Complex pulmonary vessel alterations due to an aorto-pulmonary window in adulthood", PATHOLOGE, 22(5), 2001, pp. 349-353

Abstract

An aorto-pulmonary window (aorto-pulmonary septal defect) is considered tobe a rare congenital cardiac malformation. We report the case of a patientwith an unrepaired congenital aorto-pulmonary window 1.4 cm in size which is the largest aorto-pulmonary septal defect yet reported. This patient died at the age of 58 not from the congenital cardiac malformation but from the after-effects of a pulmonary adenocarcinoma diagnosed 2 years previously. Interesting ly, the long standing, persistent pulmonary hypertension correlated well with the varying pathomorphological changes seen in the pulmonary vessels. In addition to the complex morphological signs due to the pulmonary hypertension such as the extensive aneurysms found in the left and right main pulmonary arteries (first report of this size), pulmonary vessels with relatively few pathomorphological changes were also found. Hence this first report of such a long survival of a patient with a comparatively large aorto-pulmonary septal defect demonstrates a surprising variety of pathomorphological alterations seen in the pulmonary arteries in the face of excessive pulmonary hypertension. These alterations could be the result of peripheral aneurysmatic formations and thrombembolic stenoses of the lobular or segmental arteries and might provide an explanation for the long survival ofthis particular congenital cardiac malformation. All these varying findings in the pulmonary arteries emphasise the fact that the pathomorphological findings in lung biopsies might not be representative of the whole lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:20:35