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Titolo:
PREDICTION OF OUTCOME FOR PATIENTS WITH CUTANEOUS MELANOMA
Autore:
COCHRAN AJ;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT PATHOL & LAB MED LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,SCH MED,JONSSON COMPREHENS CANC CTR LOS ANGELES CA 90095
Titolo Testata:
Pigment cell research
fascicolo: 3, volume: 10, anno: 1997,
pagine: 162 - 167
SICI:
0893-5785(1997)10:3<162:POOFPW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; LYMPH-NODE METASTASES; MALIGNANT-MELANOMA; STAGE-I; PROGNOSTIC MODELS; OCCULT MELANOMA; CELLS; ULCERATION; EXPRESSION; INVASION;
Keywords:
MELANOMA; HISTOLOGY; CLINICAL FEATURES; MOLECULAR BIOLOGY; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Cochran, "PREDICTION OF OUTCOME FOR PATIENTS WITH CUTANEOUS MELANOMA", Pigment cell research, 10(3), 1997, pp. 162-167

Abstract

Most patients with primary melanoma are cured by local surgery, but asignificant minority develop fatal metastases. The ability to identify patients with progressive disease is central to efficient management: permitting optimal deployment of adjunctive therapy and sparing the non-progressing majority the morbidity of aggressive therapy. Accurateprediction on an individual patient basis is the ideal, but the best current prognosticators permit only assignment to risk categories. Formulaic combinations of well tried correlates of outcome gender, ulceration, depth, thickness, and mitotic rate increase accuracy of prediction, hut not to personalised level. The use of large data bases againstwhich the attributes of individual patients may be compared is usefuland amalgamation of data bases will increase the availability of thisapproach. The development of markers of proliferation fraction (PCNA and MIB-1) and of the metastatic phenotype (PNA-receptor status) will further refine the process. Staging of disease is critical. Accuracy of staffing is improved by mapping the (sentinel) lymph nodes likely tocontain early tumor lymphoscintigraphy and dye/radiomarker localisation. The application of exquisitely sensitive immunohistochemical and molecular biological techniques to biopsies from tissues likely to be the site of metastases permit assessment of clinical stage with a previously impossible degree of accuracy (ultrastaging).

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Documento generato il 27/11/20 alle ore 22:22:37