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Titolo:
Sentinel node biopsy for orbital and ocular adnexal tumors
Autore:
Wilson, MW; Fleming, JC; Fleming, RM; Haik, BG;
Indirizzi:
Univ Tennessee, Hlth Sci Ctr, Dept Ophthalmol, Memphis, TN USA Univ Tennessee Memphis TN USA Sci Ctr, Dept Ophthalmol, Memphis, TN USA
Titolo Testata:
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
fascicolo: 5, volume: 17, anno: 2001,
pagine: 338 - 344
SICI:
0740-9303(200109)17:5<338:SNBFOA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOMA; LYMPHADENECTOMY; LYMPHOSCINTIGRAPHY; IDENTIFICATION; LYMPHATICS; HEAD; NECK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, MW 956 Court Ave,D-228, Memphis, TN 38163 USA 956 Court Ave,D-228Memphis TN USA 38163 Memphis, TN 38163 USA
Citazione:
M.W. Wilson et al., "Sentinel node biopsy for orbital and ocular adnexal tumors", OPHTHAL PL, 17(5), 2001, pp. 338-344

Abstract

Purpose: To describe a technique for sentinel node mapping and biopsy in patients with orbital or adnexal tumors. Methods: Five patients with orbital and adnexal tumors were studied. Two patients had malignant eyelid melanomas (one of the skin and one of the conjunctiva), one with orbital invasion. Two patients had sebaceous gland carcinoma, and one patient had a mucoepidermoid carcinoma of the conjunctiva; 500 mu Ci of Technetium-99m sulfur nanocolloid (Nycomed Amersham, Princeton, NJ) diluted to 1.0 mL was injected intradermally at the lateral canthus. The patients were positioned as they would be during surgery. Lymphoscintigraphy was performed by means of anterior, lateral, and oblique views. The tracer was followed to the first lymphatic basin, and the sentinel node was identified. Cutaneous markers were placed to denote the site. During surgery,lymphoscintigraphy scans and a hand-held gamma probe were used to locate the sentinel node. Once excised, the sentinel node was sent for histopathology. Frozen sectioning confirmed the presence of lymphoid tissue. Permanent sections with immunohistochemical markers were performed to examine for metastatic disease. Results: The sentinel node biopsy technique was applied to 5 patients withorbital and adnexal tumors. All lymph nodes were free of tumor on histopathologic examination. Conclusions: Sentinel node mapping and biopsy are possible for orbital andadnexal tumors. The morbidity of elective lymph node dissection and adjuvant radiotherapy can be avoided. Our results are preliminary, and further work must be done to identify the lymphatic basins of the orbit and ocular adnexa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:05:36