Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Histopathology and ultrastructural examination of optic nerve sheath biopsies after optic nerve sheath decompression with and without mitomycin
Autore:
Taban, M; Spoor, TC; McHenry, JG; Sadun, AA;
Indirizzi:
USC, Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA USC Los Angeles CA USA 90033 , Doheny Eye Inst, Los Angeles, CA 90033 USA
Titolo Testata:
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
fascicolo: 5, volume: 17, anno: 2001,
pagine: 332 - 337
SICI:
0740-9303(200109)17:5<332:HAUEOO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC INTRACRANIAL HYPERTENSION; GLAUCOMA FILTRATION SURGERY; PSEUDOTUMOR CEREBRI; FENESTRATION; PRESSURE; TRABECULECTOMY; MANAGEMENT; RABBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sadun, AA USC, Sch Med, Doheny Eye Inst, 1450 San Pablo St, Los Angeles, CA 90033 USA USC 1450 San Pablo St Los Angeles CA USA 90033 les, CA 90033 USA
Citazione:
M. Taban et al., "Histopathology and ultrastructural examination of optic nerve sheath biopsies after optic nerve sheath decompression with and without mitomycin", OPHTHAL PL, 17(5), 2001, pp. 332-337

Abstract

Purpose: We chose to compare histologically and ultrastructurally changes in the optic nerve sheath after optic nerve sheath decompression, initiallyafter a second surgery and after treatment with mitomycin-C. The mechanismby which optic nerve sheath decompression alleviates papilledema can be further understood in consideration of the results. Methods: Tissue was obtained by biopsy from 3 first-time surgical and 4 reoperative cases with and without mitomycin-C in patients with idiopathic intracranial hypertension. The sheaths were fixed in a mixture of 2% paraformaldehyde and 2% glutaraldehyde. osmicated and dehydrated in a series of ethanol, and finally embedded in epon. Tissue blocks were sectioned at I Am and stained with both PPD and toluidine blue. Thin sections were examined by transmission electron microscopy. Results: Normal meningeal tissue obtained at the time at optic nerve sheath decompression consisted mainly of collagen, closely packed and roughly parallel to the axis of the optic nerve. Collagen deposition seen in scar tissue after secondary optic nerve sheath decompression was extremely disorganized and irregular, with the individual fibers laid down seen-tingly at random. There was little sense of layering or of parallel arrays. Mitomycin-C appeared to influence collagen deposition in such a way that the collagen was more regularly packed and more closely resembled unoperated tissue. Conclusions. The regular well-organized collagen packing seen in normal sheath tissue is disrupted and replaced by less organized but compact scar tissue after optic nerve sheath decompression. With mitomycin use, more regular collagen packing closely approximating that found in unoperated sheath occurs. This configuration of fibers lends support for the filtration mechanism of optic nerve sheath decompression in treating papilledema.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:15:41