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Titolo:
Plasma placenta growth factor levels in midtrimester pregnancies
Autore:
Tjoa, ML; van Vugt, JMG; Mulders, MAM; Schutgens, RBH; Oudejans, CBM; van Wijk, IJ;
Indirizzi:
Vrije Univ Amsterdam, Dept Clin Chem, Med Ctr, Mol Biol Lab, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands Vrije Univ Amsterdam, Med Ctr, Dept Obstet & Gynecol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands ecol, Amsterdam, Netherlands
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 4, volume: 98, anno: 2001,
pagine: 600 - 607
SICI:
0029-7844(200110)98:4<600:PPGFLI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOVASCULAR INVASION; HUMAN CYTOTROPHOBLASTS; FACTOR EXPRESSION; FACTOR VEGF; PREECLAMPSIA; TROPHOBLAST; PHENOTYPE; OXYGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: van Wijk, IJ Vrije Univ Amsterdam, Dept Clin Chem, Med Ctr, Mol Biol Lab, de Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam de Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
M.L. Tjoa et al., "Plasma placenta growth factor levels in midtrimester pregnancies", OBSTET GYN, 98(4), 2001, pp. 600-607

Abstract

OBJECTIVE: Previous studies have shown decreased levels of placenta growthfactor in serum of pregnant women with preeclampsia. The aim of this studywas to investigate whether levels of placenta growth factor are decreased before the clinical onset of preeclampsia, and whether placenta growth factor levels are decreased in pregnancies complicated by intrauterine growth restriction. METHODS: From an ongoing longitudinal study, 101 plasma samples were collected from 72 pregnant women at weeks 11-21 of gestation. Placenta growth factor levels were determined retrospectively in plasma using an enzyme-linked immunosorbent assay. Correlations between plasma concentrations of placenta growth factor and pregnancy outcome were evaluated. RESULTS: Plasma samples of 72 patients were analyzed. Forty-four patients had no pregnancy complications, 18 developed preeclampsia, and 10 women hadpregnancies complicated by intrauterine growth restriction. Between week 17 and week 21 of pregnancy, a significantly lower level of placenta growth factor was found in plasma of patients who later developed preeclampsia (n = 10), compared with control pregnancies (n = 25, P =.004). In women with agrowth-restricted baby at birth (n = 5), levels of placenta growth factor were also low. CONCLUSIONS: Our results show that plasma placenta growth factor levels are decreased before preeclampsia, is clinically evident. The data suggest that placenta growth factor may be useful to determine the relative risk of developing preeclampsia and intrauterine growth restriction. (C) 2001 by theAmerican College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:27:26