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Titolo:
Clobetasol propionate in the treatment of premenarchal vulvar lichen sclerosus
Autore:
Smith, YR; Quint, EH;
Indirizzi:
Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t & Gynecol, Ann Arbor, MI 48109 USA
Titolo Testata:
OBSTETRICS AND GYNECOLOGY
fascicolo: 4, volume: 98, anno: 2001,
pagine: 588 - 591
SICI:
0029-7844(200110)98:4<588:CPITTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ET-ATROPHICUS; TESTOSTERONE PROPIONATE; CHILDHOOD; 0.05-PERCENT; CHILDREN; CREAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, YR Univ Michigan, Dept Obstet & Gynecol, Womens Hosp, L 4224,1500 EMed Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan L 4224,1500 E Med Ctr DrAnn Arbor MI USA 48109 SA
Citazione:
Y.R. Smith e E.H. Quint, "Clobetasol propionate in the treatment of premenarchal vulvar lichen sclerosus", OBSTET GYN, 98(4), 2001, pp. 588-591

Abstract

OBJECTIVE: To assess the effectiveness of treating premenarchal vulvar lichen sclerosus with clobetasol propionate. METHODS: A retrospective chart review was performed of girls presenting tothe University of Michigan Pediatric and Adolescent Gynecology Clinic fromJanuary, 1995, to July, 2000, with premenarchal lichen sclerosus. Subjectsin the study were treated with topical clobetasol propionate ointment 0.05% for 2-4 weeks, and then tapered to a less potent steroid. Information wasextracted concerning age at onset, symptoms, vulvar examination, previous treatments, effectiveness of clobetasol follow-up, and complications. The parents were contacted for a follow-up telephone survey. RESULTS: Fifteen girls averaging 5.7 years at the start of symptoms met criteria. The diagnosis of lichen sclerosus was made visually in I I and by biopsy in four. Follow-up ranged from 2 months to 6 years. Fourteen girls had good improvement within 4-7 weeks. One girl developed a yeast superinfection and one developed transient erythema. At least I year of follow-up by clinic visit or telephone interview was available in 11 girls. Of these 11, two girls had no further vulvar symptoms after the initial treatment, five had one or two total flares, three reported three to eight flares per year,and one girl continues to be unresponsive to therapy. CONCLUSION: Clobetasol propionate was an effective treatment of premenarchal vulvar lichen sclerosus in this small group; however, recurrences were common and required additional steroid treatment. Furthermore, complicationsof treatment were infrequent, minor, and easily treatable. (C) 2001 by theAmerican College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:39:12