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Titolo:
Lycopene, an antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation enzymes during experimental gastric carcinogenesis
Autore:
Velmurugan, B; Bhuvaneswari, V; Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Dept Biochem, Fac Sci, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
NUTRITION RESEARCH
fascicolo: 8, volume: 21, anno: 2001,
pagine: 1117 - 1124
SICI:
0271-5317(200108)21:8<1117:LAACMG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEEM LEAF EXTRACTS; 1-OXIDE-INDUCED ORAL CARCINOGENESIS; BUCCAL POUCH CARCINOGENESIS; LIPID PEROXIDES; WISTAR RATS; N-METHYL-N'-NITRO-N-NITROSOGUANIDINE; 7,12-DIMETHYLBENZANTHRACENE;
Keywords:
gastric cancer; MNNG; lycopene; lipid peroxidation; antioxidants; chemoprevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Dept Biochem, Fac Sci, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
B. Velmurugan et al., "Lycopene, an antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation enzymes during experimental gastric carcinogenesis", NUTR RES, 21(8), 2001, pp. 1117-1124

Abstract

We investigated the effects of lycopene, on hepatic oxidant-antioxidant status during N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis. The extent of lipid peroxidation and the levels of reduced glutathione, (GSH) and activities of the GSH-dependent enzymes glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were used to monitor the peroxidative balance. Enhanced lipid peroxidation in the livers of tumor-bearing animals was accompanied by significant decreases in the activities of GSH, GPx, GST and GR. Administration of lycopene significantly lowered the levels of lipid peroxides and enhanced GSH levels and activities of GSH-dependent enzymes. Our results suggest that lycopene blocks experimental gastric carcinogenesis by upregulating GSH-dependent hepatic detoxification systems thereby protecting against carcinogen-induced oxidative damage. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 13:04:52