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Titolo:
[F-18] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism
Autore:
Chida, M; Kagaya, Y; Nagata, S; Mukoyoshi, M; Namiuchi, S; Yamane, Y; Ishide, N; Watanabe, J; Takahashi, T; Ido, T; Shirato, K;
Indirizzi:
Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 iovasc Med, Sendai, Miyagi 980, Japan Tohoku Univ, Ctr Cyclotron & Radioisotope, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 dioisotope, Sendai, Miyagi 980, Japan Niigata Univ, Radioisotope Ctr, Niigata, Japan Niigata Univ Niigata Japan igata Univ, Radioisotope Ctr, Niigata, Japan
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 7, volume: 28, anno: 2001,
pagine: 815 - 819
SICI:
0969-8051(200110)28:7<815:[LDAAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION PATHWAYS; PROTEIN-KINASE-C; CARDIAC MYOCYTES; TURNOVER; 1,2-DIACYLGLYCEROLS; HEART;
Keywords:
[F-18]diacylglycerol; phosphoinositide metabolism; myocardium; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Shirato, K Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 Sendai, Miyagi 980, Japan
Citazione:
M. Chida et al., "[F-18] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism", NUCL MED BI, 28(7), 2001, pp. 815-819

Abstract

Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [F-18]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[F-18]fluorooctanoyl-2-palmitoylglycerol and1-[8-[F-18]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacyl glycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[F-18]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[F-18]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:06