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Titolo:
Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus
Autore:
Bruck, A; Portin, R; Lindell, A; Laihinen, A; Bergman, J; Haaparanta, M; Solin, O; Rinne, JO;
Indirizzi:
Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 rku PET Ctr, FIN-20520 Turku, Finland Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Univ Turku, Dept Psychol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Psychol, FIN-20520 Turku, Finland Univ Turku, Dept Rehabil, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Rehabil, FIN-20520 Turku, Finland Abo Akad Univ, Radiopharmaceut Chem & Accelerator Lab, Turku, Finland Abo Akad Univ Turku Finland ceut Chem & Accelerator Lab, Turku, Finland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 311, anno: 2001,
pagine: 81 - 84
SICI:
0304-3940(20010928)311:2<81:PETSTI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNTREATED PATIENTS; COGNITIVE DEFICITS; PERFORMANCE; DYSFUNCTION; SYSTEM; MOTOR; TESTS;
Keywords:
Parkinson's disease; positron emission tomography; [F-18]fluorodopa; caudate nucleus; frontal lobe functions; the Stroop test; cognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rinne, JO Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 r, FIN-20520 Turku, Finland
Citazione:
A. Bruck et al., "Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus", NEUROSCI L, 311(2), 2001, pp. 81-84

Abstract

We examined the relation between the dopaminergic function and the cognitive performance of patients with Parkinson's disease (PD). The subject sample consisted of ten patients in the early course of PD and with no previous antiparkinsonian medication. The dopaminergic function of the caudate nucleus and the putamen was studied with [F-18]fluorodopa positron emission tomography, and the cognitive performance with a comprehensive battery of neuropsychological tests including tests sensitive to frontal lobe function. Thedecreased [18F]fluorodopa uptake in the right caudate nucleus was found tobe related to slow processing time, measured as the difference between theincongruent and the congruent subtests of the Stroop Test (r = -0.85, P = 0.002), a similar trend was seen in the left caudate (r = -0.60, P = 0.07). Similar correlation was not detected in the putamen. The present findings provide evidence that the decreased dopanninergic function in the right caudate nucleus is related to the impaired performance in tests sensitive to frontal lobe function in patients at an early stage of PD and with no antiparkinsonian medication. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 05/04/20 alle ore 07:04:16