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Titolo:
Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
Autore:
Magill, PJ; Bolam, JP; Bevan, MD;
Indirizzi:
Univ Oxford, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England Univ Oxford Oxford England OX1 3TH armacol Unit, Oxford OX1 3TH, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 106, anno: 2001,
pagine: 313 - 330
SICI:
0306-4522(2001)106:2<313:DRTIOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LESS-THAN-1 HZ OSCILLATION; BASAL FOREBRAIN NEURONS; PASSIVE LIMB MOVEMENT; MPTP-TREATED MONKEY; PARKINSONS-DISEASE; IN-VIVO; LESIONED RATS; INTRACELLULAR ANALYSIS; FREQUENCY STIMULATION; NIGROSTRIATAL PATHWAY;
Keywords:
6-hydroxydopamine; basal ganglia; electroencephalogram; indirect pathway; oscillation; Parkinson's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Bevan, MD Univ Oxford, MRC, Anat Neuropharmacol Unit, Mansfield Rd, OxfordOX1 3TH, England Univ Oxford Mansfield Rd Oxford England OX1 3TH X1 3TH, England
Citazione:
P.J. Magill et al., "Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network", NEUROSCIENC, 106(2), 2001, pp. 313-330

Abstract

The subthalamic nucleus-lobus pallidus network plays a central role in basal ganglia function and dysfunction. To determine whether the relationship between activity in this network and the principal afferent of the basal ganglia, the cortex, is altered in a model of Parkinson's disease, we recorded unit activity in the subthalamic nucleus-globus pallidus network togetherwith cortical electroencephalogram in control and 6-hydroxydopamine-lesioned rats under urethane anaesthesia. Subthalamic, nucleus neurones in control and 6-hydroxydopamine-lesioned animals exhibited low-frequency oscillatory activity, which was tightly correlated with cortical slow-wave activity (similar to 1 Hz). The principal effect of dopamine depletion was that subthalamic nucleus neurones discharged more intensely (233% of control) and globus pallidus neurones developed low-frequency oscillatory firing patterns, without changes in mean firing rate. Ipsilateral cortical ablation largely abolished low-frequency oscillatoryactivity in the subthalamic nucleus and globus pallidus. These data suggest that abnormal low-frequency oscillatory activity in the subthalamic nucleus-globus pallidus network in the dopamine-depleted state, is generated by the inappropriate processing of rhythmic cortical input. A component (15-20%) of the network still oscillated following cortical ablation in 6-hydroxydopamine-lesioned animals, implying that intrinsic properties may also pattern activity when dopamine levels are reduced. The response of the network to global activation was altered by 6-hydroxydopariaine lesions. Subthalamic nucleus neurones were excited to a greater extent than in control animals and the majority of globus pallidus neurones were inhibited, in contrast to the excitation elicited in control animals. Inhibitory responses of g-lobus pallidus neurones were abolished by cortical ablation, suggesting that the indirect pathway is augmented abnormally during activation of the dopamine-depleted brain. Taken together, these results demonstrate that both the rate and pattern of activity of subthalamic nucleus and.-lobus pallidus neurones are altered profoundly by chronic dopamine depletion. Furthermore, the relative contribution of rate and pattern to aberrant information coding is intimately related to the state of activation of the cerebral cortex. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:19:30