Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Silent MRI infarcts and the risk of future stroke - The cardiovascular health study
Autore:
Bernick, C; Kuller, L; Dulberg, C; Longstreth, WT; Manolio, T; Beauchamp, N; Price, T;
Indirizzi:
Univ Nevada, Sch Med, Div Neurol, Las Vegas, NV 89102 USA Univ Nevada LasVegas NV USA 89102 d, Div Neurol, Las Vegas, NV 89102 USA Univ Pittsburgh, Sch Publ Hlth, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 bl Hlth, Pittsburgh, PA 15260 USA CHS Coordinating Ctr, Seattle, WA USA CHS Coordinating Ctr Seattle WA USA HS Coordinating Ctr, Seattle, WA USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA Univ, Dept Radiol, Baltimore, MD USA Univ Maryland, Dept Epidemiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Epidemiol, Baltimore, MD 21201 USA
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 57, anno: 2001,
pagine: 1222 - 1229
SICI:
0028-3878(20011009)57:7<1222:SMIATR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM PROGNOSIS; CEREBRAL INFARCTION; LACUNAR INFARCTS; ELDERLY PEOPLE; WHITE-MATTER; OLDER ADULTS; RECURRENCE; BRAIN; PREDICTORS; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bernick, C Univ Nevada, Sch Med, Div Neurol, 1707 W Charleston Blvd,220, Las Vegas, NV 89102 USA Univ Nevada 1707 W Charleston Blvd,220 Las Vegas NV USA 89102 A
Citazione:
C. Bernick et al., "Silent MRI infarcts and the risk of future stroke - The cardiovascular health study", NEUROLOGY, 57(7), 2001, pp. 1222-1229

Abstract

Background: Silent infarcts are commonly discovered on cranial MRI in the elderly. Objective: To examine the association between risk of stroke and presence of silent infarcts, alone and in combination with other stroke riskfactors. Methods: Participants (3,324) in the Cardiovascular Health Study (CHS) without a history of stroke underwent cranial MRI scans between 1992 and 1994. Silent infarcts were defined as focal lesions greater than 3 mm that were hyperintense on T2 images and, if subcortical, hypointense on T1 images. Incident strokes were identified and classified over an average follow-up of 4 years. The authors evaluated the risk of subsequent symptomatic stroke and how it was modified by other potential stroke risk factors amongthose with silent infarcts. Results: Approximately 28% of CHS participantshad evidence of silent infarcts (n = 923). The incidence of stroke was 18.7 per 1,000 person-years in those with silent infarcts (n = 67) compared with 9.5 per 1,000 person-years in the absence of silent infarcts. The adjusted relative risk of incident stroke increased with multiple (more than one)silent infarcts (hazard ratio 1.9 [1.2 to 2.8]). Higher values of diastolic and systolic blood pressure, common and internal carotid wall thickness, and the presence of atrial fibrillation were associated with an increased risk of strokes in those with silent infarcts (n = 53 strokes). Conclusion: The presence of silent cerebral infarcts on MRI is an independent predictorof the risk of symptomatic stroke over a 4-year follow-up in older individuals without a clinical history of stroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:22:15