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Titolo:
Relationship between severity of MR perfusion deficit and DWI lesion evolution
Autore:
Thijs, VN; Adami, A; Neumann-Haefelin, T; Moseley, ME; Marks, MP; Albers, GW;
Indirizzi:
Univ Frankfurt, Dept Neurol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 eurol, D-6000 Frankfurt, Germany Univ Verona, Neurol Clin, I-37100 Verona, Italy Univ Verona Verona ItalyI-37100 ona, Neurol Clin, I-37100 Verona, Italy Katholieke Univ Leuven, UZ Gasthuisberg, Dept Neurol, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3000 l, B-3000 Louvain, Belgium Stanford Univ, Med Ctr, Dept Radiol, Neuroradiol Sect, Palo Alto, CA 94304USA Stanford Univ Palo Alto CA USA 94304 oradiol Sect, Palo Alto, CA 94304USA Stanford Univ, Med Ctr, Dept Neurol & Neurol Sci, Stanford Stroke Ctr, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 Stroke Ctr, Palo Alto, CA 94304 USA
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 57, anno: 2001,
pagine: 1205 - 1211
SICI:
0028-3878(20011009)57:7<1205:RBSOMP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; ACUTE ISCHEMIC STROKE; SUSCEPTIBILITY CONTRAST MRI; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; WEIGHTED MRI; CEREBROVASCULAR-DISEASE; DWI/PWI MISMATCH; TRANSIT-TIME; DIFFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Thijs, VN Katholieke Univ Leuven, UZ Gasthuisberg, Dept Neurol, Herestr 49, B-3000 Louvain, Belgium Katholieke Univ Leuven Herestr 49 Louvain Belgium B-3000 elgium
Citazione:
V.N. Thijs et al., "Relationship between severity of MR perfusion deficit and DWI lesion evolution", NEUROLOGY, 57(7), 2001, pp. 1205-1211

Abstract

Objective: To assess whether a quantitative analysis of the severity of the early perfusion deficit on MRI in acute ischemic stroke predicts the evolution of the perfusion/diffusion mismatch and to determine thresholds of hypoperfusion that can distinguish between critical and noncritical hypoperfusion. Methods: Patients with acute ischemic stroke were studied in whom perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI MRI) wereperformed within 7 hours of symptom onset and again after 4 to 7 days. Patients with early important decreases in points on the NIH Stroke Scale wereexcluded. Maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were created. These hemodynamic parameters werecorrelated with the degree of recruitment of the baseline PWI lesion by the DWI lesion. Results: Twelve patients had an initial PWI > DWI mismatch of> 20%. A linear relationship was observed between the initial MTT and the degree of recruitment of the baseline PWI lesion by the DWI lesion at follow-up (R-2 = 0.9, p < 0.001). Higher CBV values were associated with higher degrees of recruitment (p= 0.732, p < 0.007). The volume of MTT of >4 (R-2 = 0.86, p < 0.001) or >6 seconds (R-2 = 0.85, p < 0.001) predicted final infarct size. Conclusion: Among patients who have had an acute stroke with PWI > DWI, who do not have dramatic early clinical improvement, the degree ofexpansion of the initial DWI lesion correlates with the severity of the initial perfusion deficit as measured by the mean transit time and the cerebral blood volume.

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Documento generato il 23/01/20 alle ore 03:33:05