Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blood pressure changes induced by arterial blood withdrawal influence boldsignal in anesthesized rats at 7 tesla: Implications for pharmacologic MRI
Autore:
Kalisch, R; Elbel, GK; Gossl, C; Czisch, M; Auer, DP;
Indirizzi:
NMR, Max Planck Inst Psychiat, Munich, Germany NMR Munich GermanyNMR, Max Planck Inst Psychiat, Munich, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 4, volume: 14, anno: 2001,
pagine: 891 - 898
SICI:
1053-8119(200110)14:4<891:BPCIBA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMORRHAGIC HYPOTENSION; QUANTITATIVE ASSESSMENT; OXYGENATION LEVEL; IN-VIVO; BRAIN; AUTOREGULATION; FLOW; VOLUME; ACTIVATION; ISOFLURANE;
Keywords:
magnetic resonance imaging; brain; rat; fMRI; pharmacologic MRI; phMRI; blood pressure; hemorrhage; anesthesia; 7 Tesla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kalisch, R NMR, Max Planck Inst Psychiat, Munich, Germany NMR Munich Germany Max Planck Inst Psychiat, Munich, Germany
Citazione:
R. Kalisch et al., "Blood pressure changes induced by arterial blood withdrawal influence boldsignal in anesthesized rats at 7 tesla: Implications for pharmacologic MRI", NEUROIMAGE, 14(4), 2001, pp. 891-898

Abstract

Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-dependent (BOLD) contrast is now increasingly applied for measuring drug effects on brain activity. A possible confound in pharmacologic fMRI (phMRI) is that the BOLD signal may be sensitive to systemic cardiovascular orrespiratory parameters, which can themselves be modulated by a drug. To assess whether abrupt changes in arterial blood pressure (BP) as may be observed in phMRI experiments influence the BOLD signal, a hemorrhage model was studied in anesthesized rats at 7 T using spin-echo EPI. BP and BOLD signaltime courses were found to be significantly correlated (P < 0.01). This effect was detected under the three different anesthetic regimens employed (isoflurane, halothane, and propofol). The regional pattern of BP-BOLD correlations was heterogeneous and may reflect vascular density. In physiologicalterms, a BOLD decrease during a decrease in BP may result from an increasein mostly venous cerebral blood volume (CBV) as an autoregulatory responseto maintain cerebral blood flow (CBF) during decreased perfusion pressure. The observed influence of BP on BOLD may complicate qualitative and quantitative description of drug effects. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:28:42