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Titolo:
A pulsed neural network model of bursting in the basal ganglia
Autore:
Humphries, MD; Gurney, KN;
Indirizzi:
Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England UnivSheffield Sheffield S Yorkshire England S10 2TP S Yorkshire, England
Titolo Testata:
NEURAL NETWORKS
fascicolo: 6-7, volume: 14, anno: 2001,
pagine: 845 - 863
SICI:
0893-6080(200107/09)14:6-7<845:APNNMO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE SUBTHALAMIC NUCLEUS; SINGLE-SPIKE ACTIVITY; PRIMARY MOTOR CORTEX; RAT NEOSTRIATUM; GLOBUS-PALLIDUS; FIRING MODE; NEURONS; THALAMUS; INFORMATION; PARKINSONISM;
Keywords:
spiking neuron; STN; GPe; basal ganglia; Ca2+ currents; noise; compartmental model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Humphries, MD Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TP ngland
Citazione:
M.D. Humphries e K.N. Gurney, "A pulsed neural network model of bursting in the basal ganglia", NEURAL NETW, 14(6-7), 2001, pp. 845-863

Abstract

We present new techniques for extending the functionality of spiking neurons which allow the incorporation of several aspects of neuron function previously confined to the domain of low level ion-channel based models. These aspects include spontaneous (or endogenous) firing, the complex interactionof multiple ion-species and the spatial distribution of synaptic contacts over the cell membrane. These ideas are applied to a neural circuit consisting of the cortex and a subset of the nuclei in the basal ganglia-the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe). This circuit has been studied extensively in vitro by Plenz and Kitai [Plenz, D., & Kitai, S. T. (1999). A basal ganglia pacemaker formed by the subthalamic nucleus and external glob-as pallidus. Nature, 400 677-682] whose data we use to constrain our model. With respect to this circuit, we have obtained three main results. First, that its characteristic burst firing is due to a Ca2+ current mediated mechanism. Second, that noise can assist in the generation of bursting and, paradoxically, stabilise the network behaviour under synaptic weight variations. Third, that a variety of dendritic processing is necessary in order to obtain the full range of bursting behaviour. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:59:34