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Titolo:
Cytokines and acute neurodegeneration
Autore:
Allan, SM; Rothwell, NJ;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 10, volume: 2, anno: 2001,
pagine: 734 - 744
SICI:
1471-0048(200110)2:10<734:CAAN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA; TEMPORAL-LOBE EPILEPSY; PRECURSOR PROTEIN EXPRESSION; MESSENGER-RNA EXPRESSION; LONG-TERM POTENTIATION; TRAUMATIC BRAIN INJURY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Allan, SM Univ Manchester, Sch Biol Sci, 1-124 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 1-124 Stopford Bldg,OxfordRd Manchester Lancs England M13 9PT
Citazione:
S.M. Allan e N.J. Rothwell, "Cytokines and acute neurodegeneration", NAT REV NEU, 2(10), 2001, pp. 734-744

Abstract

Cytokines have been implicated as mediators and inhibitors of diverse forms of neurodegeneration. They are induced in response to brain injury and have diverse actions that can cause, exacerbate, mediate and/or inhibit cellular injury and repair, Here we review evidence for the contribution of cytokines to acute neurodegeneration, focusing primarily on interleukin 1 (IL-1), tumour necrosis factor-alpha (TNF alpha) and transforming growth factor-beta (TGF beta). TGF beta seems to exert primarily neuroprotective actions,whereas TNF alpha might contribute to neuronal injury and exert protectiveeffects. IL-1 mediates ischaemic, excitotoxic and traumatic brain injury, probably through multiple actions on glia, neurons and the vasculature. Understanding cytokine action in acute neurodegeneration could lead to novel and effective therapeutic strategies, some of which are already in clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:47:16