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Titolo:
Rapid formation and remodeling of postsynaptic densities in developing dendrites
Autore:
Marrs, GS; Green, SH; Dailey, ME;
Indirizzi:
Univ Iowa, Dept Biol Sci, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Biol Sci, Iowa City, IA 52242 USA Univ Iowa, Program Neurosci, Med Labs 1178, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Med Labs 1178, Iowa City, IA 52242 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 10, volume: 4, anno: 2001,
pagine: 1006 - 1013
SICI:
1097-6256(200110)4:10<1006:RFAROP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC PLASTICITY; NERVOUS-SYSTEM; SLICE CULTURES; AREA CA1; SPINES; RAT; SYNAPSES; PROTEIN; ACTIN; FILOPODIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Dailey, ME Univ Iowa, Dept Biol Sci, 335 Biol Bldg, Iowa City, IA 52242 USA Univ Iowa 335 Biol Bldg Iowa City IA USA 52242 ty, IA 52242 USA
Citazione:
G.S. Marrs et al., "Rapid formation and remodeling of postsynaptic densities in developing dendrites", NAT NEUROSC, 4(10), 2001, pp. 1006-1013

Abstract

The dynamics of postsynaptic density (PSD) formation and remodeling were investigated in live developing hippocampal tissue slices. Time lapse imaging of transfected neurons expressing GFP-tagged PSD95, a prominent PSD protein, revealed that up to 40% of PSDs in developing dendrites are structurally dynamic; they rapidly (<15 min) appear or disappear, but also grow, shrink and move within shafts and spines. New spines containing Ms were formed by conversion of dynamic filopodia-like spine precursors in which PSDs appeared de novo, or by direct extension of spines or spine precursors carrying preformed PSDs from the shaft. Ms are therefore highly dynamic structures that can undergo rapid structural alteration within dendrite shafts, spines and spine precursors, permitting rapid formation and remodeling of synapticconnections in developing CNS tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:43:28