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Titolo:
Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics
Autore:
Poncer, JC; Malinow, R;
Indirizzi:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab Cold Spring Harbor NY USA 11724 rbor, NY 11724 USA Inst Pasteur, INSERM, U261, F-75015 Paris, France Inst Pasteur Paris France F-75015 r, INSERM, U261, F-75015 Paris, France
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 10, volume: 4, anno: 2001,
pagine: 989 - 996
SICI:
1097-6256(200110)4:10<989:PCOSSD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PAIRED-PULSE FACILITATION; NEOCORTICAL PYRAMIDAL NEURONS; NEUROTRANSMITTER RELEASE; TRANSMITTER RELEASE; GLUTAMATE RELEASE; HIPPOCAMPAL SLICE; AMPA RECEPTORS; NMDA RECEPTORS; DENTATE GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Poncer, JC Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab 1 Bungtown Rd Cold Spring Harbor NY USA 11724
Citazione:
J.C. Poncer e R. Malinow, "Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics", NAT NEUROSC, 4(10), 2001, pp. 989-996

Abstract

Synaptic transmission relies on both the gain and the dynamics of synapses. Activity-dependent changes in synaptic gain are well-documented at excitatory synapses and may represent a substrate for information storage in the brain. Here we examine the mechanisms of changes in transmission dynamics at excitatory synapses. We show that paired-pulse ratios (PPRs) of AMPAR andNMDAR EPSCs onto dentate gyrus granule cells are often different; this difference is reduced during LTP, reflecting PPR changes of AMPAR but not NMDAR EPSCs. Presynaptic manipulations, however, produce parallel changes in AMPAR and NMDAR EPSCs. LTP at these synapses reflects a reduction in the proportion of silent synapses lacking functional AMPARs. Changes in PPR during LTP therefore reflect the initial difference between PPRs of silent and functional synapses. Functional conversion of silent synapses permits postsynaptic sampling from additional release sites and thereby affects the dynamics and gain of signals conveyed between neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:55:04