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Titolo:
Immunotherapy through TCR gene transfer
Autore:
Kessels, HWHG; Wolkers, MC; van den Boom, MD; van der Valk, MA; Schumacher, TNM;
Indirizzi:
Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Netherlands Canc Inst, Div Mol Genet, Dept Expt Anim Pathol, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 957 - 961
SICI:
1529-2908(200110)2:10<957:ITTGT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; BONE-MARROW TRANSPLANTATION; HEMATOPOIETIC STEM-CELLS; VERSUS-HOST DISEASE; INFLUENZA PNEUMONIA; ADOPTIVE TRANSFER; LYMPHOCYTES; EXPRESSION; METHYLATION; SPECIFICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schumacher, TNM Netherlands Canc Inst, Div Immunol, Plesmanlaan 121, NL-1066 CX Amsterdam,Netherlands Netherlands Canc Inst Plesmanlaan 121 Amsterdam Netherlands NL-1066 CX
Citazione:
H.W.H.G. Kessels et al., "Immunotherapy through TCR gene transfer", NAT IMMUNOL, 2(10), 2001, pp. 957-961

Abstract

The antigen specificity of T lymphocytes is dictated solely by the T cell receptor (TC R) a and P chains. Consequently, genetic transfer of TCR chains may be an appealing strategy with which to impose a desirable virus- or tumor-antigen specificity onto cytotoxic or helper T cell populations. We describe here the genetic introduction of a virus-specific TCR into peripheral T cells in a mouse model system. These experiments showed that T cells redirected by TCR gene transfer expanded upon viral infection of mice and efficiently homed to effector sites. In this setting,TCR gene transfer was notassociated with any significant autoimmune pathology. In addition, small numbers of TCR-transduced T cells promoted the rejection of antigen-expressing tumors in vivo. These data suggest that the redirection of T cells by TCR gene transfer is a viable strategy for the rapid induction of virus- or tumor-specific immunity.

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Documento generato il 05/04/20 alle ore 04:00:43