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Titolo:
Dendritic cells signal T cells in the absence of exogenous antigen
Autore:
Kondo, T; Cortese, I; Markovic-Plese, S; Wandinger, KP; Carter, C; Brown, M; Leitman, S; Martin, R;
Indirizzi:
NINCDS, Cellular Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 oimmunol Branch, NIH, Bethesda, MD 20892 USA NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 Transfus Med, Ctr Clin, Bethesda, MD 20892 USA NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA20892 xpt Immunol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 932 - 938
SICI:
1529-2908(200110)2:10<932:DCSTCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II MOLECULES; MULTIPLE-SCLEROSIS; ACTIVATION; RECEPTOR; SURVIVAL; COMPLEX; PEPTIDE; DIFFERENTIATION; LYMPHOCYTES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, R NINCDS, Cellular Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 ranch, NIH, Bethesda, MD 20892 USA
Citazione:
T. Kondo et al., "Dendritic cells signal T cells in the absence of exogenous antigen", NAT IMMUNOL, 2(10), 2001, pp. 932-938

Abstract

Interactions with self-major histocompatibility complex molecules on dendritic cells (DCs) are important for the survival of mature CD4(+)T cells. Wehave followed the DC-mediated signal from the T cell surface to the nucleus and identified a pattern of activation that correlates with increased in vitro survival. This response is induced exclusively by DCs and is likely associated with a modulation of the T cell activation threshold. We have also found that DC-mediated activation results in antigen-independent cytokinegene expression, which points to a new role for DCs in shaping the cytokine milieu. Such antigen-independent activation of T cells may play a role inprotective immunity, but may also induce and perpetuate autoimmune states such as multiple sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:49:04