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Titolo:
Functional antigen-independent synapses formed between T cells and dendritic cells
Autore:
Revy, P; Sospedra, M; Barbour, B; Trautmann, A;
Indirizzi:
CNRS, UPR415, Lab Immunopharmacol Mol, Inst Cochin Genet Mol, Paris, France CNRS Paris France nopharmacol Mol, Inst Cochin Genet Mol, Paris, France Ecole Normale Super, CNRS, UMR 8544, Neurobiol Lab, F-75005 Paris, France Ecole Normale Super Paris France F-75005 biol Lab, F-75005 Paris, France
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 925 - 931
SICI:
1529-2908(200110)2:10<925:FASFBT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM; IMMUNOLOGICAL SYNAPSE; IMMUNE-RESPONSES; TRANSGENIC MICE; ACTIVATION; SURVIVAL; CD4(+); LYMPHOCYTES; RECOGNITION; NAIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Trautmann, A CNRS, UPR415, Lab Immunopharmacol Mol, Inst Cochin Genet Mol,Paris, France CNRS Paris France ol, Inst Cochin Genet Mol, Paris, France
Citazione:
P. Revy et al., "Functional antigen-independent synapses formed between T cells and dendritic cells", NAT IMMUNOL, 2(10), 2001, pp. 925-931

Abstract

Immunological synapse formation is usually assumed to require antigen recognition by T cell receptors. However, the immunological synapse formed at the interface between naive T cells and dendritic cells (DCs) has never beendescribed. We show here that in the absence of antigen, and even of major histocompatibility complex molecules,T cell-DC synapses are formed and leadto several T cell responses: a local increase in tyrosine phosphorylation,small Ca2+ responses, weak proliferation and long-term survival. These responses are triggered more readily in CD4(+)T cells than in CD8(+)T cells, which express a specific isoform of the repulsive molecule CD43. These phenomena may play a major role in the maintenance of the naive T cell pool in vivo.

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Documento generato il 18/02/20 alle ore 14:16:30