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Titolo:
Final steps of natural killer cell maturation: a model for type 1 type 2 differentiation?
Autore:
Loza, MJ; Perussia, B;
Indirizzi:
Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Dept Microbiol& Immunol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 917 - 924
SICI:
1529-2908(200110)2:10<917:FSONKC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATORY FACTOR INTERLEUKIN-12; BLOOD MONONUCLEAR-CELLS; HUMAN NK CELLS; CUTTING EDGE; T-CELLS; CYTOKINE; EXPRESSION; LYMPHOCYTES; SUBSET; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Perussia, B Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Dept Microbiol& Immunol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 PA 19107 USA
Citazione:
M.J. Loza e B. Perussia, "Final steps of natural killer cell maturation: a model for type 1 type 2 differentiation?", NAT IMMUNOL, 2(10), 2001, pp. 917-924

Abstract

Analysis of cytokine and differentiation antigen expression in human natural killer (NK) cells revealed that interleukin 13 (IL-13) and interferon gamma (IFN-gamma) are produced at sequential stages during irreversible IL-12-induced differentiation. In human NK cell clones, polyclonal CD3(-)CD161(+)CD56(-) cells and peripheral lymphocytes, IL-4 induced the proliferation of both IL-13. NK and T cells, whereas IL-12 allowed a proliferation-independent accumulation of IFN-gamma (+) cells. These data disproved the NK1-NK2 hypothesis and challenge the current T helper 1 (THI)-T(H)2 paradigm. We propose that the cytokine environment regulates a type 2 -->0 -->1 developmental progression, with IL-12 needed for terminal differentiation and IL-4 delaying this process, rather than a type 1 versus type 2 decision of a type 0 cell.

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Documento generato il 29/03/20 alle ore 14:55:11