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Titolo:
Nitric oxide and the immune response
Autore:
Bogdan, C;
Indirizzi:
Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 907 - 916
SICI:
1529-2908(200110)2:10<907:NOATIR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHASE-DEFICIENT MICE; NADPH PHAGOCYTE OXIDASE; NECROSIS-FACTOR-ALPHA; NATURAL-KILLER-CELLS; CD4(+) T-CELLS; NO SYNTHASE; REACTIVE NITROGEN; INTERFERON-GAMMA; ARGININOSUCCINATE SYNTHETASE; AUTOIMMUNE-DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
189
Recensione:
Indirizzi per estratti:
Indirizzo: Bogdan, C Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, Wasserturmstr 3-5, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Wasserturmstr 3-5 Erlangen Germany D-91054
Citazione:
C. Bogdan, "Nitric oxide and the immune response", NAT IMMUNOL, 2(10), 2001, pp. 907-916

Abstract

During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system. It is involved in the pathogenesis and control of infectious diseases, tumors, autoimmune processes and chronic degenerative diseases. Because of its variety of reaction partners (DNA, proteins, low-molecular weight thiols, prosthetic groups, reactive oxygen intermediates), its widespread production (by three different NOsynthases (NOS) and the fact that its activity is strongly influenced by its concentration, NO continues to surprise and perplex immunologists. Today, there is no simple, uniform picture of the function of NO in the immune system. Protective and toxic effects of NO are frequently seen in parallel. Its striking inter- and intracellular signaling capacity makes it extremelydifficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 19:37:50