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Titolo:
TGF-beta signaling in tumor suppression and cancer progression
Autore:
Derynck, R; Akhurst, RJ; Balmain, A;
Indirizzi:
Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, Program Dev Biol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 2, volume: 29, anno: 2001,
pagine: 117 - 129
SICI:
1061-4036(200110)29:2<117:TSITSA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; CELL-CYCLE ARREST; HUMAN-BREAST-CANCER; RECEPTOR-TYPE-II; MAMMARY EPITHELIAL-CELLS; N-TERMINAL KINASE; ACTIVATOR INHIBITOR-1 GENE; COLON-CARCINOMA CELLS; HUMAN PROSTATE-CANCER; HUMAN HEPATOMA-CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
312
Recensione:
Indirizzi per estratti:
Indirizzo: Derynck, R Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program,San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA94143 94143 USA
Citazione:
R. Derynck et al., "TGF-beta signaling in tumor suppression and cancer progression", NAT GENET, 29(2), 2001, pp. 117-129

Abstract

Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorigenesis. The consequent changes in cell behavior and responsiveness result not only from genetic alterations such as activation of oncogenes or inactivation of tumor suppressor genes, but also from altered production of, or responsiveness to, stimulatory or inhibitory growth and differentiation factors. Among these, transforming growth factor beta (TGF-beta) and its signaling effectors act as key determinants of carcinoma cell behavior. The autocrine and paracrine effects of TGF-beta on tumor cells and the tumor micro-environment exertboth positive and negative influences on cancer development. Accordingly, the TGF-beta signaling pathway has been considered as both a tumor suppressor pathway and a promoter of tumor progression and invasion. Here we evaluate the role of TGF-beta in tumor development and attempt to reconcile the positive and negative effects of TGF-beta in carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:45:09