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Titolo:
Drosophila APC2 and Armadillo participate in tethering mitotic spindles tocortical actin
Autore:
McCartney, BM; McEwen, DG; Grevengoed, E; Maddox, P; Bejsovec, A; Peifer, M;
Indirizzi:
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Biol, Chapel Hill, NC 27599 USA Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USAUniv N Carolina Chapel Hill NC USA 27599 c Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Biol, Chapel Hill, NC 27599 USA Duke Univ, Dept Biol, Durham, NC 27708 USA Duke Univ Durham NC USA 27708Duke Univ, Dept Biol, Durham, NC 27708 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 10, volume: 3, anno: 2001,
pagine: 933 - 938
SICI:
1465-7392(200110)3:10<933:DAAAPI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR PROTEIN; EPITHELIAL-CELLS; ADHERENS JUNCTION; BETA-CATENIN; ORGANIZATION; HOMOLOG; MICROTUBULES; ASSOCIATION; CADHERIN; DYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Peifer, M Univ N Carolina, Dept Biol, CB 3280, Chapel Hill, NC 27599 USA Univ N Carolina CB 3280 Chapel Hill NC USA 27599 l, NC 27599 USA
Citazione:
B.M. McCartney et al., "Drosophila APC2 and Armadillo participate in tethering mitotic spindles tocortical actin", NAT CELL BI, 3(10), 2001, pp. 933-938

Abstract

Proper positioning of mitotic spindles ensures equal allocation of chromosomes to daughter cells. This often involves interactions between spindle and astral microtubules and cortical actin(1). In yeast and Caenorhabditis elegans, some of the protein machinery that connects spindles and cortex has been identified but, in most animal cells, this process remains mysterious. Here, we report that the tumour suppresser homologue APC2 and its binding partner Armadillo both play roles in spindle anchoring during the syncytialmitoses of early Drosophila embryos. Armadillo, alpha -catenin and APC2 all localize to sites of cortical spindle attachment. APC2-Armadillo complexes often localize with interphase microtubules. Zeste-white 3 kinase, which can phosphorylate Armadillo and APC, is also crucial for spindle positioning and regulates the localization of APC2-Armadillo complexes. Together, these data suggest that APC2, Armadillo and alpha -catenin provide an important link between spindles and cortical actin, and that this link is regulatedby Zeste-white 3 kinase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:02:21