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Titolo:
Spatial control of the actin cytoskeleton in Drosophila epithelial cells
Autore:
Baum, B; Perrimon, N;
Indirizzi:
Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 d Inst, Dept Genet, Boston, MA 02115 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 10, volume: 3, anno: 2001,
pagine: 883 - 890
SICI:
1465-7392(200110)3:10<883:SCOTAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ASSOCIATED PROTEIN; ABL TYROSINE KINASE; PROFILIN; POLYMERIZATION; MUTATIONS; OOGENESIS; POLARITY; MOTILITY; DOMAINS; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Baum, B Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA02115 on, MA 02115 USA
Citazione:
B. Baum e N. Perrimon, "Spatial control of the actin cytoskeleton in Drosophila epithelial cells", NAT CELL BI, 3(10), 2001, pp. 883-890

Abstract

The actin cytoskeleton orders cellular space and transduces many of the forces required for morphogenesis. Here we combine genetics and cell biology to identify genes that control the polarized distribution of actin filaments within the Drosophila follicular epithelium. We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex. In contrast, CAP-a Drosophila homologue of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament formation catalysed by Ena at apical cell junctions. The Abl tyrosine kinase also collaborates in this process. We therefore propose that CAP, Ena and Abl act in concert to modulate the subcellular distribution of actin filaments in Drosophila.

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Documento generato il 30/03/20 alle ore 19:51:41