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Titolo:
Borg proteins control septin organization and are negatively regulated by Cdc42
Autore:
Joberty, G; Perlungher, RR; Sheffield, PJ; Kinoshita, M; Noda, M; Haystead, T; Macara, IG;
Indirizzi:
Univ Virginia, Markey Ctr Cell Signaling, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Kyoto Univ, Grad Sch Med, Dept Mol Oncol, Sakyo Ku, Kyoto, Japan Kyoto Univ Kyoto Japan Sch Med, Dept Mol Oncol, Sakyo Ku, Kyoto, Japan Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 10, volume: 3, anno: 2001,
pagine: 861 - 866
SICI:
1465-7392(200110)3:10<861:BPCSOA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDRICH-SYNDROME PROTEIN; ACUTE MYELOID-LEUKEMIA; GTPASE-BINDING DOMAIN; N-WASP; PLASMA-MEMBRANE; CELL-POLARITY; YEAST; COMPLEX; GENE; REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Macara, IG Univ Virginia, Markey Ctr Cell Signaling, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 ville, VA 22908 USA
Citazione:
G. Joberty et al., "Borg proteins control septin organization and are negatively regulated by Cdc42", NAT CELL BI, 3(10), 2001, pp. 861-866

Abstract

The Cdc42 GTPase binds to numerous effector proteins that control cell polarity, cytoskeletal remodelling and vesicle transport. In many cases the signalling pathways downstream of these effectors are not known. Here we showthat the Cdc42 effectors Borg1 to Borg3 bind to septin GTPases. Endogenousseptin Cdc10 and Borg3 proteins can be immunoprecipitated together by an anti-Borg3 antibody. The ectopic expression of Borgs disrupts normal septin organization. Cdc42 negatively regulates this effect and inhibits the binding of Borg3 to septins. Borgs are therefore the first known regulators of mammalian septin organization and provide an unexpected link between the septin and Cdc42 GTPases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:17:25