Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk
Autore:
Pfau, W; Martin, FL; Cole, KJ; Weaver, G; Marquardt, H; Phillips, DH; Grover, PL;
Indirizzi:
Inst Canc Res, Haddow Labs, Sutton SM2 5NG, Surrey, England Inst Canc ResSutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England Univ Hamburg, Sch Med, Dept Toxicol, D-22527 Hamburg, Germany Univ Hamburg Hamburg Germany D-22527 t Toxicol, D-22527 Hamburg, Germany Queen Charlottes & Chelsea Hosp, Dept Paediat, London W12 0HS, England Queen Charlottes & Chelsea Hosp London England W12 0HS W12 0HS, England
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 498, anno: 2001,
pagine: 207 - 217
SICI:
1383-5718(20011115)498:1-2<207:MTOCMF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROCYCLIC AROMATIC-AMINES; BREAST-CANCER ETIOLOGY; DNA-ADDUCTS; MCL-5 CELLS; COMET ASSAY; RISK; ACTIVATION; INDUCTION; DAMAGE; TISSUE;
Keywords:
morphological transformation; human milk extracts; breast cancer; Ames test; micronucleus assay; comet assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, DH Inst Canc Res, Haddow Labs, Cotswold Rd, Sutton SM2 5NG, Surrey, England Inst Canc Res Cotswold Rd Sutton Surrey England SM2 5NG gland
Citazione:
W. Pfau et al., "Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk", MUT RES-GTE, 498(1-2), 2001, pp. 207-217

Abstract

Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk from UK-resident women (n = 7) were tested for their abilities to morphologically transform C3H/M2 mouse fibroblasts. Genotoxicities were assessed in the Salmonella typhimurium reverse-mutation assay in the presence of S9 using strains TA1538 and YG1019, and in metabolically-competent human MCL-5 cells with the micronucleus and with the alkaline single cell gel electrophoresis (comet) assays. Two of the seven extracts were inactive in the transformation assay both in the presence or absence of S9, two appeared to be equally transforming either in the presence or absence of S9, and two other extracts induced increased transformation frequencies in the presence of S9. A seventh extract, tested only in the absence of S9, was inactive. Extracts were either active or inactive in at least three of the four tests applied. Four extracts were active or inactive in all four tests. The results suggest that human milk could beused as a resource for investigations of the as-yet-unidentified transforming agents previously detected in mammary lipid. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:30:02