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Titolo:
Sex chromosome loss, micronuclei, sister chromatid exchange and aging: a study including 16 centenarians
Autore:
Bukvic, N; Gentile, M; Susca, F; Fanelli, M; Serio, G; Buonadonna, L; Capurso, A; Guanti, G;
Indirizzi:
Policlin, DIMIMP Sez Genet Med, I-70124 Bari, Italy Policlin Bari Italy I-70124 n, DIMIMP Sez Genet Med, I-70124 Bari, Italy IRCCS S DEBELLIS, Castellanza, Italy IRCCS S DEBELLIS Castellanza ItalyIRCCS S DEBELLIS, Castellanza, Italy Policlin, DIMIMP Cattedra Stat Med, I-70124 Bari, Italy Policlin Bari Italy I-70124 IMIMP Cattedra Stat Med, I-70124 Bari, Italy Policlin, Dipartimento Clin Med Immunol & Malattie Infett, I-70124 Bari, Italy Policlin Bari Italy I-70124 munol & Malattie Infett, I-70124 Bari, Italy
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 498, anno: 2001,
pagine: 159 - 167
SICI:
1383-5718(20011115)498:1-2<159:SCLMSC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; HUMAN-POPULATION SAMPLE; IN-SITU HYBRIDIZATION; X-CHROMOSOME; STATION ATTENDANTS; EXPOSED WORKERS; AGE; FREQUENCY; ANEUPLOIDY; SCE;
Keywords:
FISH; sex chromosome loss; micronuclei; sister chromatid exchange; aging; centenarians;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Guanti, G Policlin, DIMIMP Sez Genet Med, Pzza G Cesare, I-70124 Bari, Italy Policlin Pzza G Cesare Bari Italy I-70124 , I-70124 Bari, Italy
Citazione:
N. Bukvic et al., "Sex chromosome loss, micronuclei, sister chromatid exchange and aging: a study including 16 centenarians", MUT RES-GTE, 498(1-2), 2001, pp. 159-167

Abstract

In the present study we analysed the possible effect of age, sex and smoking on the mean values of micronucleus (MN) and sister chromatid exchange (SCE) frequencies on peripheral blood obtained from 38 subjects ranging in age from 16 to 63 years and 16 centenarians. The mean number of binucleated cells with micronuclei varied in function of age and sex (as demonstrated bythe analysis of covariance (F = 13.13; P < 0.001), particularly evident was the increment observed in women with increasing age (interaction age/sex:F = 5.53; P < 0.05). Smoking habits had no effects on MN frequency (F = 0.36; P > 0.05). Sex (F = 4.18; P < 0.05) and smoking habits (F = 14.64; P < 0.001) influenced significantly SCE per cell frequencies, but age had no effects on them (F = 2.45; P < 0.05). The age-associated increase of sex chromosome loss was studied using fluorescence in situ hybridisation (FISH) on interphase nuclei. The loss of Y signals was observed in similar to 10% of interphase cells from the centenarians males, that is six times more often than in the younger control men (similar to1.6%). The frequency of X signal loss (similar to1.7%) in young women was similar to that observed in male controls of the same age but the incidence of the X chromosome aneuploidy in centenarian females was appreciably higher (similar to 22%) than that found for the Y chromosome in males. These results were correlated with the data on MN formationand a positive correlation between the percentage of aneuploid cells (FISH) and MN values was observed (r = 0.50; P < 0.05). (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:38:04