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Titolo:
Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures
Autore:
Nefic, H;
Indirizzi:
Fac Sci Sarajevo, Dept Genet, Sarajevo 71000, Bosnia & Herceg Fac Sci Sarajevo Sarajevo Bosnia & Herceg 71000 o 71000, Bosnia & Herceg
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 498, anno: 2001,
pagine: 89 - 98
SICI:
1383-5718(20011115)498:1-2<89:AEOVCO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGES; CHINESE-HAMSTER CELLS; BONE-MARROW CELLS; ASCORBIC-ACID; ANTICANCER DRUGS; DNA-DAMAGE; MUTAGENIC ACTIVITY; MAMMALIAN-CELLS; IN-VITRO; ANTIOXIDANTS;
Keywords:
vitamin C; cisplatin; chromosomal aberrations; anticlastogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Nefic, H Fac Sci Sarajevo, Dept Genet, Zmaja Bosne 33-35, Sarajevo 71000, Bosnia & Herceg Fac Sci Sarajevo Zmaja Bosne 33-35 Sarajevo Bosnia & Herceg 71000
Citazione:
H. Nefic, "Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures", MUT RES-GTE, 498(1-2), 2001, pp. 89-98

Abstract

Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damageinduced by different agents. The protective effect of Vitamin C on cisplatin induced chromosome aberrations has been determined in the human peripheral lymphocyte chromosome aberration test in vitro. The results of treatments with Vitamin C indicated that it statistically significantly decreases the number of chromosome aberrations and number of metaphases with aberrations induced with cisplatin, but it can not completely protect cells from damage. The test concentrations of Vitamin C (10 and 100 mug/ml) had a limited antimutagen effect on cisplatin (0.5 mug/ml), which can cause genetic damage through free radical mechanisms. The antimutagen effect included the anticlastogenic effect of Vitamin C and its ability to decrease the number of aneuploid mitoses. Vitamin C showed the most efficient anticlastogenic effect during simultaneous treatment with cisplatin. Also, Vitamin C reduced cell toxicity of cisplatin during simultaneous treatment. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:59:14