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Titolo:
The ubc2 gene of Ustilago maydis encodes a putative novel adaptor protein required for filamentous growth, pheromone response and virulence
Autore:
Mayorga, ME; Gold, SE;
Indirizzi:
Univ Georgia, Dept Plant Pathol, Athens, GA 30602 USA Univ Georgia AthensGA USA 30602 Dept Plant Pathol, Athens, GA 30602 USA
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 6, volume: 41, anno: 2001,
pagine: 1365 - 1379
SICI:
0950-382X(200109)41:6<1365:TUGOUM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAP KINASE CASCADE; MATING-TYPE LOCUS; CRYPTOCOCCUS-NEOFORMANS; SACCHAROMYCES-CEREVISIAE; CANDIDA-ALBICANS; SIGNALING SPECIFICITY; FUNGAL PATHOGEN; CAMP; IDENTIFICATION; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, SE 1 Kendal Sq,Bldg 1400 W, Cambridge, MA 02139 USA 1 Kendal Sq,Bldg 1400 W Cambridge MA USA 02139 dge, MA 02139 USA
Citazione:
M.E. Mayorga e S.E. Gold, "The ubc2 gene of Ustilago maydis encodes a putative novel adaptor protein required for filamentous growth, pheromone response and virulence", MOL MICROB, 41(6), 2001, pp. 1365-1379

Abstract

The Basidiomycete fungus Ustilago maydis causes corn smut disease and alternates between a budding haploid saprophyte and a filamentous dikaryotic pathogen. Previous work demonstrated that haploid adenylate cyclase (uac1) mutants display a constitutively filamentous phenotype. Suppressor mutants ofa uac1 disruption strain, named ubc for Ustilago bypass of cyclase, no longer require cAMP for the budding morphology. The ubc2 gene was isolated by complementation and is required for filamentous growth. The deduced amino acid sequence encoded by ubc2 shows localized homology to Sterile Alpha Motif (SAM), Ras Association (RA) and Src homology 3 (SH3) protein-protein interaction domains. A K78E missense mutation within the SAM domain, revealed agenetic interaction between ubc2 and ubc4, a pheromone-responsive MAP kinase kinase kinase, This indicates involvement of ubc2 in the pheromone-responsive MAP kinase cascade and ubc2 is required for pheromone-responsive morphogenesis. The ubc2 gene is a critical virulence factor. Thus, ubc2 encodesa putative novel adaptor protein that may act directly upstream of the pheromone-responsive MAP kinase cascade in U. maydis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:06:04