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Titolo:
Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats
Autore:
Rousseau, D; Helies-Toussaint, C; Raederstorff, D; Moreau, D; Grynberg, A;
Indirizzi:
Fac Pharm, INRA NASA, F-75270 Paris, France Fac Pharm Paris France F-75270 c Pharm, INRA NASA, F-75270 Paris, France F Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4002 asel, Switzerland Fac Med, LPPCE, Dijon, France Fac Med Dijon FranceFac Med, LPPCE, Dijon, France
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 225, anno: 2001,
pagine: 109 - 119
SICI:
0300-8177(2001)225:1-2<109:DNPFAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ARTERY STENOSIS; FISH-OIL; BLOOD-PRESSURE; ONE-CLIP; DOCOSAHEXAENOIC ACID; REVERSIBLE ALTERATIONS; EICOSAPENTAENOIC ACID; PROSTANOID SYNTHESIS; HEART; PHOSPHOLIPIDS;
Keywords:
hypertension; heart; PUFA; nutrition; prevention; perindopril; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Grynberg, A Fac Pharm, INRA NASA, 4 Ave Observ, F-75270 Paris, France Fac Pharm 4 Ave Observ Paris France F-75270 270 Paris, France
Citazione:
D. Rousseau et al., "Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats", MOL C BIOCH, 225(1-2), 2001, pp. 109-119

Abstract

The consequences of a dietary n-3 PUFA supply was investigated on the blood pressure (BP) increase elicited by left renal artery stenosis in rats distributed in 3 groups (n = 8) fed for 8 weeks a semi-purified diet either ascontrol diet or enriched diets (docosahexaenoic acid, DHA, or eicosapentaenoic acid, EPA). The PUFA intake induced large alterations in heart and kidney phospholipid fatty acid profile, but did not influence body weight, cardiac hypertrophy, renal left atrophy and right hypertrophy. Within 4 weeks,BP raised from 120-180 +/- 2 mm Hg in the control group, but only to 165 +/- 3 mm Hg in the n-3 PUFA groups. After stabilization of BP in the 3 groups, the rats received a short administration of increasing dose of perindopril. The lower dose (0.5 mg/kg) moderately decreased BP only in the control group. With higher doses (1, 5 and 10 mg/kg) BP was normalized in the 3 groups, with a higher amplitude of the BP lowering effect in the control group. A moderate n-3 PUFA intake can contribute to prevent the development of peripheral hypertension in rats by a mechanism that may involve angiotensin converting enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:36:07