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Titolo:
In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine
Autore:
Nagasawa, T; Yonekura, T; Nishizawa, N; Kitts, DD;
Indirizzi:
Iwate Univ, Fac Agr, Dept Agrobiosci, Morioka, Iwate 0208550, Japan Iwate Univ Morioka Iwate Japan 0208550 sci, Morioka, Iwate 0208550, Japan Univ British Columbia, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 225, anno: 2001,
pagine: 29 - 34
SICI:
0300-8177(2001)225:1-2<29:IVAIVI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; DIPEPTIDES; ANSERINE; NITRILOTRIACETATE; MALONDIALDEHYDE; PRODUCTS; COPPER; BRAIN; ZINC; RAT;
Keywords:
carnosine; TBARS; protein carbonyl content; histidine; muscle; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Nagasawa, T Iwate Univ, Fac Agr, Dept Agrobiosci, 3-18-8 Ueda, Morioka, Iwate 0208550,Japan Iwate Univ 3-18-8 Ueda Morioka Iwate Japan 0208550 08550,Japan
Citazione:
T. Nagasawa et al., "In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine", MOL C BIOCH, 225(1-2), 2001, pp. 29-34

Abstract

Carnosine, a beta -alanyl-L-histidine dipeptide with antioxidant properties is present at high concentrations in skeletal muscle tissue. In this study, we report on the antioxidant activity of carnosine on muscle lipid and protein stability from both in vitro and in vivo experiments. Carnosine inhibited lipid peroxidation and oxidative modification of protein in muscle tissue prepared from rat hind limb homogenates exposed to in vitro Fenton reactant (Fe2+, H2O2)-generated free radicals. The minimum effective concentrations of carnosine for lipid and protein oxidation were 2.5 and 1 mM, respectively. Histidine and beta -alanine, active components of carnosine, showed no individual effect towards inhibiting either lipid or protein oxidation. Skeletal muscle of rats fed a histidine supplemented diet for 13 days exhibited a marked increase in carnosine content with a concomitant reduction in muscle lipid peroxidation and protein carbonyl content in skeletal muscle caused by subjecting rats to a Fe-nitrilotriacetate administration treatment. This significant in vitro result confirms the in vivo antioxidant activity of carnosine for both lipid and protein constituents of muscle under physiological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:04:15