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Titolo:
Studies of a targeted risk reduction intervention through defined exercise(STRRIDE)
Autore:
Kraus, WE; Torgan, CE; Duscha, BD; Norris, J; Brown, SA; Cobb, FR; Bales, CW; Annex, BH; Samsa, GP; Houmard, JA; Slentz, CA;
Indirizzi:
Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC 27710 USA Duke UnivDurham NC USA 27710 Dept Med, Div Cardiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Med, Div Geriatr, Durham, NC 27710 USA Duke UnivDurham NC USA 27710 Dept Med, Div Geriatr, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Med, Div Gen Internal Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Div Gen Internal Med, Durham, NC 27710 USA Duke Univ, Med Ctr, Ctr Hlth Policy Res, Duke Ctr Living, Durham, NC 27710USA Duke Univ Durham NC USA 27710 y Res, Duke Ctr Living, Durham, NC 27710USA Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA DukeUniv Durham NC USA 27710 ommunity & Family Med, Durham, NC 27710 USA E Carolina Univ, Human Performance Lab, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 nce Lab, Greenville, NC 27858 USA E Carolina Univ, Dept Exercise & Sport Sci, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 ort Sci, Greenville, NC 27858 USA Vet Adm Med Ctr, Dept Med, Durham, NC USA Vet Adm Med Ctr Durham NC USAVet Adm Med Ctr, Dept Med, Durham, NC USA Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Durham, NC USA Vet Adm Med Ctr Durham NC USA tr Geriatr Res Educ & Clin, Durham, NC USA
Titolo Testata:
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
fascicolo: 10, volume: 33, anno: 2001,
pagine: 1774 - 1784
SICI:
0195-9131(200110)33:10<1774:SOATRR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; TIME PHYSICAL-ACTIVITY; UNITED-STATES RAILROAD; HARVARD ALUMNI HEALTH; SKELETAL-MUSCLE; INSULIN SENSITIVITY; PLASMA-LIPOPROTEINS; IN-VIVO; MEN; ADAPTATIONS;
Keywords:
exercise training; insulin resistance; dyslipidemia; capillary density; muscle biopsy; muscle fiber type; aerobic capacity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kraus, WE Duke Univ, Med Ctr, Dept Med, Div Cardiol, Box 3327, Durham, NC 27710 USA Duke Univ Box 3327 Durham NC USA 27710 327, Durham, NC 27710 USA
Citazione:
W.E. Kraus et al., "Studies of a targeted risk reduction intervention through defined exercise(STRRIDE)", MED SCI SPT, 33(10), 2001, pp. 1774-1784

Abstract

Purpose: The Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trial is a randomized controlled clinical trial designed to study the effects of exercise training regimens differing in dose (kcal.wk(-1)) and/or intensity (relative to peak (V) over dotO(2)) on established cardiovascular risk factors and to investigate the peripheral biologic mechanisms through which chronic physical activity alters carbohydrate and lipid metabolism to result in improvements in these parameters of cardiovascular risk in humans. Methods: We will recruit 384 subjects and randomlyassign them to one of three exercise training regimens or to a sedentary control group. The recruiting goal is to attain a subject population that is50% female and 30% ethnic minority. The overall strategy is to use graded exercise training regimens in moderately overweight subjects with impairments in insulin action and mild to moderate lipid abnormalities to investigate whether there are dose or intensity effects and whether adaptations in skeletal muscle (fiber type, metabolic capacity, and/or capillary surface area) account for improvements in insulin action and parameters of lipoproteinmetabolism. We will study these variables before and after exercise training, and over the course of a 2-wk detraining period. The study sample size is chosen to power the study to examine differences in responses between subjects of different gender and ethnicity to exercise training with respect to the least sensitive parameter-skeletal muscle capillary density. Results: The driving hypothesis is that improvements in cardiovascular risk parameters derived from habitual exercise are primarily mediated through adaptations occurring in skeletal muscle. Conclusion: Identification that amount and intensity of exercise matter for achieving general and specific health benefits and a better understanding of the peripheral mechanisms mediating the responses in carbohydrate and lipid metabolism to chronic physical activity will lead to better informed recommendations for those undertaking an exercise program to improve cardiovascular risk.

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Documento generato il 29/09/20 alle ore 08:40:37