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Titolo:
Health-related quality of life in multiple myeloma patients receiving high-dose chemotherapy with autologous blood stem-cell support
Autore:
Gulbrandsen, N; Wisloff, F; Brinch, L; Carlson, K; Dahl, IM; Gimsing, P; Hippe, E; Hjorth, M; Knudsen, LM; Lamvik, J; Lenhoff, S; Lofvenberg, E; Nesthus, I; Nielsen, JL; Turesson, L; Westin, J;
Indirizzi:
Univ Oslo, Ulleval Hosp, Dept Hematol, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 val Hosp, Dept Hematol, N-0407 Oslo, Norway
Titolo Testata:
MEDICAL ONCOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 65 - 77
SICI:
1357-0560(2001)18:1<65:HQOLIM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OF-LIFE; MELPHALAN-PREDNISONE; RANDOMIZED TRIAL; THERAPY; TRANSPLANTATION; SURVIVAL; QLQ-C30; YOUNGER; SCORES;
Keywords:
adult; hematopoetic stem-cell transplantation; melphalan; multiple myeloma; neoplasms; prospective studies; quality of life; questionnaires;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Gulbrandsen, N Univ Oslo, Ulleval Hosp, Dept Hematol, N-0407 Oslo, Norway Univ Oslo Oslo Norway N-0407 Hematol, N-0407 Oslo, Norway
Citazione:
N. Gulbrandsen et al., "Health-related quality of life in multiple myeloma patients receiving high-dose chemotherapy with autologous blood stem-cell support", MED ONCOL, 18(1), 2001, pp. 65-77

Abstract

In a population-based study, the Nordic Myeloma Study Group found a survival advantage for high-dose melphalan with autologous blood stem-cell support compared to conventional chemotherapy in myeloma patients under 60 yr of age (risk ratio: 1.62; confidence interval [CI] 1.222-2.15; p=0.001). A study of health-related quality of life (HRQoL) was integrated in the trial, using the EORTC QLQ-C30 questionnaire. Of the 274 patients receiving intensive therapy 221 (81%) were compared to 113 (94%) of 120 patients receiving conventional melphalan-prednisone treatment. Prior to treatment, there were no statistically significant differences inany HRQoL score between the two groups. One month after the start of induction chemotherapy, the patients on intensive treatment had more sleep disturbance than the control patients. At 6 mo, corresponding to a mean of 52 d after high-dose melphalan, the patients on intensive treatment had moderately lower scores for global QoL and role and social functioning and there was also a significantly higher score for appetite loss. At 12 and 24 mo, theHRQoL was similar to that of the control patients. At 36 mo, there was a trend toward less fatigue, pain, nausea, and appetite loss in the intensive-treatment group. Thus, the 18 mo of prolonged survival seem to be associated with a good health-related quality of life. Despite the moderate HRQoL reduction associated with the early intensive chemotherapy phase, this treatment modality must be regarded as an important step forward in the care of multiple myeloma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:43:52