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Titolo:
Serum S100 beta protein as a marker of disease activity in patients with malignant melanoma
Autore:
Mohammed, MQ; Abraha, HD; Sherwood, RA; MacRae, K; Retsas, S;
Indirizzi:
Charing Cross Hosp, Dept Med Oncol, Melanoma Unit, London W6 8RF, England Charing Cross Hosp London England W6 8RF ma Unit, London W6 8RF, England
Titolo Testata:
MEDICAL ONCOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 109 - 120
SICI:
1357-0560(2001)18:2<109:SSBPAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED METASTATIC MELANOMA; AMERICAN JOINT COMMITTEE; S-100 PROTEIN; CUTANEOUS MELANOMA; BLOOD; STAGE;
Keywords:
serum; S100; LDH; melanoma; metastatic; tumor markers; treatment; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Retsas, S Charing Cross Hosp, Dept Med Oncol, Melanoma Unit, Fulam Palace Rd, LondonW6 8RF, England Charing Cross Hosp Fulam Palace Rd London England W6 8RF ngland
Citazione:
M.Q. Mohammed et al., "Serum S100 beta protein as a marker of disease activity in patients with malignant melanoma", MED ONCOL, 18(2), 2001, pp. 109-120

Abstract

The purpose of the study was to evaluate serum S100 beta protein as a marker of disease activity in patients with malignant melanoma (MM) and compareit with serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). One hundred sixty-four patients with MM, stages I-IV according to the American Joint Committee on Cancer (AJCC), were studied. Recurrent disease was categorized as active (AD) if metastases were evident clinically or with imaging investigations and inactive (ID) if no metastases were apparent at thetime of sample collection. The sensitivity and specificity of S100 beta, LDH, and ALP for discrimination between AD and ID were calculated using receiver-operating characteristic curve (ROC) analysis. Serum S100 beta, LDH, and ALP concentrations were significantly higher in AD compared to ID. SerumS100 beta protein was the best discriminator between AD and ID, the areas under the ROC curve being 0.89, 0.71, and 0.70 for S100 beta, LDH, and ALP,respectively. Serum S100 beta and LDH levels (both p < 0.0001) and serum ALP levels (p = 0.0014) corresponded with the number of metastatic sites involved. Using a cutoff point of 0.20 <mu>g/L for serum S100 beta protein, a specificity of 93% with a sensitivity of 68% was obtained for AD in MM. In stage IV disease, S100 was an independent predictor of survival in univariate (p = 0.001; hazard ratio = 1.0156) and multivariate (p = 0.038; hazard ratio = 1.0108) analyses. Serum S100 beta protein is a better indicator of disease activity in MM than LDH or ALP and is an independent predictor of survival in stage IV disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:11:59