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Titolo:
BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development
Autore:
Patzke, H; Reissmann, E; Stanke, M; Bixby, JL; Ernsberger, U;
Indirizzi:
Max Planck Inst Hirnforsch, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany Univ Miami, Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 l & Cellular Pharmacol, Miami, FL 33101 USA Univ Miami, Sch Med, Neurosci Program, Miami, FL 33101 USA Univ Miami Miami FL USA 33101 Med, Neurosci Program, Miami, FL 33101 USA Univ Heidelberg, Inst Anat & Zellbiol 3, Interdisziplinares Zentrum Neurowissensch, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 108, anno: 2001,
pagine: 149 - 159
SICI:
0925-4773(200110)108:1-2<149:BGFAPT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NERVOUS-SYSTEM; NEUROTRANSMITTER PHENOTYPE; TYROSINE-HYDROXYLASE; PRECURSOR CELLS; EXPRESSION; DIFFERENTIATION; GENES; PROTEINS; TARGET; NEUROGENINS;
Keywords:
neurexin; synaptotagmin; sympathetic; induction; bone morphogenetic protein; Phox2; neuronal; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ernsberger, U Max Planck Inst Hirnforsch, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 rmany
Citazione:
H. Patzke et al., "BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development", MECH DEVEL, 108(1-2), 2001, pp. 149-159

Abstract

Synaptotagmin I and neurexin I mRNAs, coding for proteins involved in neurotransmitter secretion, become detectable in primary sympathetic ganglia shortly after initial induction of the noradrenergic transmitter phenotype. To test whether the induction of these more general neuronal genes is mediated by signals known to initiate noradrenergic differentiation in a neuronalsubpopulation, we examined their expression in noradrenergic neurons induced by ectopic overexpression of growth and transcription factors. Overexpression of BMP4 or Phox2a in vivo results in synaptotagmin I and neurexin I expression in ectopically located noradrenergic cells. In vitro, BMP4 initiates synaptotagmin I and neurexin I expression in addition to tyrosine hydroxylase induction. Thus, the induction of synaptotagmin I and neurexin I, which are expressed in a large number of different neuron populations, can beaccomplished by growth and transcription factors available only to a subset of neurons. These findings suggest that the initial expression of proteins involved in neurotransmitter secretion is regulated by different signals in different neuron populations. (C) 2001 Elsevier Science Ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:00:52